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Fbxw4 Gene Detail
Summary
  • Symbol
    Fbxw4
  • Name
    F-box and WD-40 domain protein 4
  • Synonyms
    dactylin, dactylyn, Fbw4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354698
    NCBI Gene: 30838
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:45566693-45648751 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.75 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2230 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354698
 protein coding gene Chr19:45566693-45648954 (-)
129S1/SvImJ ENSMUSG00200019954
 protein coding gene Chr19:42271364-42353890 (-)
A/J ENSMUSG00195014805
 protein coding gene Chr19:42406474-42489038 (-)
AKR/J ENSMUSG00220018404
 protein coding gene Chr19:42206136-42288678 (-)
BALB/cJ ENSMUSG00180017735
 protein coding gene Chr19:42658784-42741334 (-)
C3H/HeJ ENSMUSG00175006275
 protein coding gene Chr19:42200959-42282956 (-)
C57BL/6NJ ENSMUSG00215004426
 protein coding gene Chr19:42263514-42345586 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023018
 protein coding gene Chr19:42233832-42316506 (-)
CAST/EiJ ENSTCUG00005015406
 protein coding gene Chr19:41844737-41927680 (-)
CBA/J ENSMUSG00210017848
 protein coding gene Chr19:42280540-42362536 (-)
DBA/2J ENSMUSG00185008865
 protein coding gene Chr19:42782329-42864866 (-)
FVB/NJ ENSMUSG00205029845
 protein coding gene Chr19:41695019-41777550 (-)
JF1/MsJ ENSUMUG00000017516
 protein coding gene Chr19:42924814-43008355 (-)
LP/J ENSMUSG00230024553
 protein coding gene Chr19:43541125-43623645 (-)
NOD/ShiLtJ ENSMUSG00190005060
 protein coding gene Chr19:42143634-42226170 (-)
NZO/HlLtJ ENSMUSG00225042547
 protein coding gene Chr19:47135352-47217885 (-)
PWK/PhJ ENSLUMG00010000976
 protein coding gene Chr19:42091794-42174753 (-)
SPRET/EiJ ENSMSPG00010007060
 protein coding gene Chr19:41836515-41918735 (-)
WSB/EiJ ENSIUOG00005006173
 protein coding gene Chr19:41643632-41726139 (-)



Homology
more
  • Human Ortholog
    FBXW4, F-box and WD repeat domain containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXW4, F-box and WD repeat domain containing 4
  • Synonyms
    DAC, FBW4, FBWD4, SHFM3, SHSF3
  • Links
    NCBI Gene ID: 6468
    UniProt: P57775

  • Chr Location
    10q24.32; chr10:101610663-101695295 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous null mutation lack feet except for a single fused digit and die prenatally. Heterozygotes, in the presence of a recessive modifying allele, show loss of digits, frequently with fused metatarsal and metacarpal bones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    667
  • Tissues
    38
  • cDNA Data
    68
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040913 Ensembl Gene Model | MGI Sequence Detail 82059 C57BL/6J ±  kb
    transcript ENSMUST00000046869 Ensembl | MGI Sequence Detail 2068 Not Applicable  
    polypeptide ENSMUSP00000036505 Ensembl | MGI Sequence Detail 410 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 2
      cDNA 68
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-8791, MGI:94857
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 12
      Diseases 2
      Gene Ontology 4
      Phenotypes 18
    • Earliest
      J:6607 Chai CK, Dactylaplasia in mice a two-locus model for development anomalies. J Hered. 1981 Jul-Aug;72(4):234-7
    • Latest
      J:370676 Glaser J, et al., Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes. Nat Genet. 2025 Jul;57(7):1766-1776
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory