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Ddx25 Gene Detail
Summary
  • Symbol
    Ddx25
  • Name
    DEAD box helicase 25
  • Synonyms
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 25, GRTH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353582
    NCBI Gene: 30959
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:35453144-35469766 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.31 cM, cytoband A3-A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    537 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353582
 protein coding gene Chr9:35447943-35469824 (-)
129S1/SvImJ ENSMUSG00200037644
 protein coding gene Chr9:32426977-32448861 (-)
A/J ENSMUSG00195046449
 protein coding gene Chr9:32218404-32240289 (-)
AKR/J ENSMUSG00220045488
 protein coding gene Chr9:32258819-32280735 (-)
BALB/cJ ENSMUSG00180042584
 protein coding gene Chr9:32346723-32368607 (-)
C3H/HeJ ENSMUSG00175045337
 protein coding gene Chr9:32347905-32369790 (-)
C57BL/6NJ ENSMUSG00215027152
 protein coding gene Chr9:32347595-32369476 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031956
 protein coding gene Chr9:31169942-31192130 (-)
CAST/EiJ ENSTCUG00005042997
 protein coding gene Chr9:32318860-32340621 (-)
CBA/J ENSMUSG00210043942
 protein coding gene Chr9:32358795-32380718 (-)
DBA/2J ENSMUSG00185036312
 protein coding gene Chr9:32398800-32420715 (-)
FVB/NJ ENSMUSG00205031491
 protein coding gene Chr9:32713456-32735340 (-)
JF1/MsJ ENSUMUG00000039046
 protein coding gene Chr9:32583086-32604946 (-)
LP/J ENSMUSG00230029225
 protein coding gene Chr9:32823247-32845015 (-)
NOD/ShiLtJ ENSMUSG00190020989
 protein coding gene Chr9:32476284-32498198 (-)
NZO/HlLtJ ENSMUSG00225020601
 protein coding gene Chr9:32791276-32813050 (-)
PWK/PhJ ENSLUMG00010038873
 protein coding gene Chr9:32464441-32486333 (-)
SPRET/EiJ ENSMSPG00010032218
 protein coding gene Chr9:32894408-32911694 (-)
WSB/EiJ ENSIUOG00005041209
 protein coding gene Chr9:31920183-31942102 (-)



Homology
more
  • Human Ortholog
    DDX25, DEAD-box helicase 25
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX25, DEAD-box helicase 25
  • Synonyms
    GRTH
  • Links
    NCBI Gene ID: 29118
    UniProt: Q9UHL0

  • Chr Location
    11q24.2; chr11:125903328-125943702 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display male infertility, arrest of spermatogenesis at step 8, abnormal Leydig cells, and increased germ cell apoptosis in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    3
  • cDNA Data
    46
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30959 NCBI Gene Model | MGI Sequence Detail 16623 C57BL/6J ±  kb
    transcript NM_013932 RefSeq | MGI Sequence Detail 1675 C57BL/6  
    polypeptide Q9QY15 UniProt | EBI | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143278
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 18
    • Earliest
      J:59130 Tang PZ, et al., A novel gonadotropin-regulated testicular RNA helicase. A new member of the dead-box family. J Biol Chem. 1999 Dec 31;274(53):37932-40
    • Latest
      J:337868 Anbazhagan R, et al., miRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA-miRNA Network Analysis. Cells. 2023 Feb 27;12(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory