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Sspn Gene Detail
Summary
  • Symbol
    Sspn
  • Name
    sarcospan
  • Synonyms
    Krag
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353511
    NCBI Gene: 16651
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:145877367-145910949 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 77.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    549 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353511
 protein coding gene Chr6:145860423-145910951 (+)
129S1/SvImJ ENSMUSG00200003415
 protein coding gene Chr6:143420468-143454067 (+)
A/J ENSMUSG00195007903
 protein coding gene Chr6:142326759-142360365 (+)
AKR/J ENSMUSG00220030661
 protein coding gene Chr6:140565395-140598433 (+)
BALB/cJ ENSMUSG00180015512
 protein coding gene Chr6:142453961-142487563 (+)
C3H/HeJ ENSMUSG00175002438
 protein coding gene Chr6:142368102-142398891 (+)
C57BL/6NJ ENSMUSG00215013376
 protein coding gene Chr6:142531410-142564998 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029052
 protein coding gene Chr6:143713171-143746871 (+)
CAST/EiJ ENSTCUG00005010390
 protein coding gene Chr6:143163332-143196492 (+)
CBA/J ENSMUSG00210004351
 protein coding gene Chr6:142438900-142472485 (+)
DBA/2J ENSMUSG00185015645
 protein coding gene Chr6:143080965-143111760 (+)
FVB/NJ ENSMUSG00205028742
 protein coding gene Chr6:141402406-141435687 (+)
JF1/MsJ ENSUMUG00000004611
 protein coding gene Chr6:141732313-141765367 (+)
LP/J ENSMUSG00230005137
 protein coding gene Chr6:144181901-144215500 (+)
NOD/ShiLtJ ENSMUSG00190001438
 protein coding gene Chr6:142907113-142940394 (+)
NZO/HlLtJ ENSMUSG00225012573
 protein coding gene Chr6:147071382-147102233 (+)
PWK/PhJ ENSLUMG00010032607
 protein coding gene Chr6:140821606-140852418 (+)
SPRET/EiJ ENSMSPG00010015059
 protein coding gene Chr6:144731834-144761566 (+)
WSB/EiJ ENSIUOG00005022147
 protein coding gene Chr6:143114788-143148387 (+)



Homology
more
  • Human Ortholog
    SSPN, sarcospan
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SSPN, sarcospan
  • Synonyms
    DAGA5, KRAG, NSPN, SPN1, SPN2
  • Links
    NCBI Gene ID: 8082
    UniProt: Q14714

  • Chr Location
    12p12.1; chr12:26121991-26299290 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal muscle histology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    608
  • Tissues
    6
  • cDNA Data
    42
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030255 Ensembl Gene Model | MGI Sequence Detail 33583 C57BL/6J ±  kb
    transcript ENSMUST00000032383 Ensembl | MGI Sequence Detail 4431 Not Applicable  
    polypeptide ENSMUSP00000032383 Ensembl | MGI Sequence Detail 216 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 2
      cDNA 42
      Primer pair 3
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16701, MGI:99905
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:12009 George DL, et al., Amplified DNA in Y1 mouse adrenal tumor cells: isolation of cDNAs complementary to an amplified c-Ki-ras gene and localization of homologous sequences to mouse chromosome 6. Nucleic Acids Res. 1984 Mar 26;12(6):2731-43
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory