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Tnfrsf19 Gene Detail
Summary
  • Symbol
    Tnfrsf19
  • Name
    tumor necrosis factor receptor superfamily, member 19
  • Synonyms
    TAJ, TAJ-ALPHA, TRADE, Troy
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352474
    NCBI Gene: 29820
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:61201324-61283939 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 32.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2143 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352474
 protein coding gene Chr14:61201283-61284304 (-)
129S1/SvImJ ENSMUSG00200039158
 protein coding gene Chr14:49792685-49875186 (-)
A/J ENSMUSG00195030435
 protein coding gene Chr14:49966842-50050138 (-)
AKR/J ENSMUSG00220028350
 protein coding gene Chr14:49314061-49397371 (-)
BALB/cJ ENSMUSG00180050620
 protein coding gene Chr14:49588725-49672028 (-)
C3H/HeJ ENSMUSG00175044727
 protein coding gene Chr14:51328577-51411082 (-)
C57BL/6NJ ENSMUSG00215048662
 protein coding gene Chr14:49527856-49610662 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019379
 protein coding gene Chr14:52128548-52217953 (-)
CAST/EiJ ENSTCUG00005048517
 protein coding gene Chr14:51245933-51328653 (-)
CBA/J ENSMUSG00210044472
 protein coding gene Chr14:49954898-50038189 (-)
DBA/2J ENSMUSG00185029823
 protein coding gene Chr14:55126289-55208790 (-)
FVB/NJ ENSMUSG00205030222
 protein coding gene Chr14:49458992-49541792 (-)
JF1/MsJ ENSUMUG00000044468
 protein coding gene Chr14:66315287-66398564 (-)
LP/J ENSMUSG00230035653
 protein coding gene Chr14:67155954-67238449 (-)
NOD/ShiLtJ ENSMUSG00190045518
 protein coding gene Chr14:49760711-49843508 (-)
NZO/HlLtJ ENSMUSG00225045453
 protein coding gene Chr14:57502287-57585084 (-)
PWK/PhJ ENSLUMG00010045927
 protein coding gene Chr14:49213567-49296369 (-)
SPRET/EiJ ENSMSPG00010031342
 protein coding gene Chr14:52626708-52715638 (-)
WSB/EiJ ENSIUOG00005040608
 protein coding gene Chr14:49183202-49266624 (-)



Homology
more
  • Human Ortholog
    TNFRSF19, TNF receptor superfamily member 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF19, TNF receptor superfamily member 19
  • Synonyms
    TAJ, TAJ-alpha, TRADE, TROY
  • Links
    NCBI Gene ID: 55504
    UniProt: Q9NS68

  • Chr Location
    13q12.12; chr13:23570370-23676104 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit no obvious physical abnormalities or alterations in behavior, locomotion, or fecundity, however neurons are more resistant to the suppressive action of myelin inhibitors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    891
  • Tissues
    135
  • cDNA Data
    22
  • Literature Summary
    33
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060548 Ensembl Gene Model | MGI Sequence Detail 82616 C57BL/6J ±  kb
transcript ENSMUST00000111236 Ensembl | MGI Sequence Detail 3958 Not Applicable  
polypeptide ENSMUSP00000106867 Ensembl | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016483 tumor necrosis factor receptor superfamily member 19
    (term hierarchy)
  • InterPro Domains
    IPR001368 TNFR/NGFR cysteine-rich region
    IPR060024 TNFRSF19/27, second TNFR Cys domain
    IPR034047 Tumor necrosis factor receptor 19, N-terminal
    IPR047526 Tumor necrosis factor receptor superfamily member 19/27/EDAR
    IPR022342 Tumour necrosis factor receptor 19
  • GlyGen
    Q9JLL3 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 29
    cDNA 22
    Primer pair 4
    Other 3
    Antibodies 3

    Microarray probesets 6
Other
Accession IDs
less
MGI:1890132, MGI:2145715, MGI:2145803
References
more
  • Summaries
    All 85
    Developmental Gene Expression 33
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:58926 Hu S, et al., Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Genomics. 1999 Nov 15;62(1):103-7
  • Latest
    J:390120 Trowe MO, et al., Mesenchymal WNT signaling coordinates epithelial and mesenchymal differentiation in the developing murine ureter. Cell Commun Signal. 2026 Jul 21;24(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory