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Sh2d3c Gene Detail
Summary
  • Symbol
    Sh2d3c
  • Name
    SH2 domain containing 3C
  • Synonyms
    Cas/HEF1-associated signal transducer, Chat, Nsp3, SH2-containing Eph receptor-binding protein 1, Shep1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351631
    NCBI Gene: 27387
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32611072-32645008 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.09 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    837 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351631
 protein coding gene Chr2:32611067-32645524 (+)
129S1/SvImJ ENSMUSG00200047913
 protein coding gene Chr2:29583563-29618030 (+)
A/J ENSMUSG00195041631
 protein coding gene Chr2:29686870-29721348 (+)
AKR/J ENSMUSG00220048858
 protein coding gene Chr2:29804778-29839250 (+)
BALB/cJ ENSMUSG00180053780
 protein coding gene Chr2:29699608-29734082 (+)
C3H/HeJ ENSMUSG00175051158
 protein coding gene Chr2:29666025-29700489 (+)
C57BL/6NJ ENSMUSG00215045273
 protein coding gene Chr2:29731521-29765991 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023446
 protein coding gene Chr2:28594859-28629700 (+)
CAST/EiJ ENSTCUG00005052299
 protein coding gene Chr2:29411785-29446661 (+)
CBA/J ENSMUSG00210016600
 protein coding gene Chr2:29738560-29773019 (+)
DBA/2J ENSMUSG00185049771
 protein coding gene Chr2:29600122-29634599 (+)
FVB/NJ ENSMUSG00205045703
 protein coding gene Chr2:29446874-29481345 (+)
JF1/MsJ ENSUMUG00000047527
 protein coding gene Chr2:29484019-29518987 (+)
LP/J ENSMUSG00230041435
 protein coding gene Chr2:31518877-31553337 (+)
NOD/ShiLtJ ENSMUSG00190050581
 protein coding gene Chr2:29701257-29735720 (+)
NZO/HlLtJ ENSMUSG00225008609
 protein coding gene Chr2:39271935-39306768 (+)
PWK/PhJ ENSLUMG00010046613
 protein coding gene Chr2:29580180-29615026 (+)
SPRET/EiJ ENSMSPG00010045856
 protein coding gene Chr2:30285600-30321130 (+)
WSB/EiJ ENSIUOG00005049120
 protein coding gene Chr2:29547796-29582684 (+)



Homology
more
  • Human Ortholog
    SH2D3C, SH2 domain containing 3C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH2D3C, SH2 domain containing 3C
  • Synonyms
    CHAT, NSP3, PRO34088, SHEP1
  • Links
    NCBI Gene ID: 10044
    UniProt: Q8N5H7

  • Chr Location
    9q34.11; chr9:127738317-127778727 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality with absence of gastric milk. Surviving mice exhibit abnormal olfactory bulb innervation, fewer gonadotrophin positive cells in the hypothalamus, and decreased testes size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    9
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27387 NCBI Gene Model | MGI Sequence Detail 33937 C57BL/6J ±  kb
    transcript NM_001412523 RefSeq | MGI Sequence Detail 3557 C57BL/6  
    polypeptide Q9QZS8 UniProt | EBI | MGI Sequence Detail 854 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000014816 SH2 domain-containing protein 3C
      (term hierarchy)
    • InterPro Domains
      IPR051853 Adapter protein with SH2 and Ras-GEF domains
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR044102 SHEP1/BCAR3/NSP1, SH2 domain
    • GlyGen
      Q9QZS8 7 sites, 1 O-linked glycan (7 sites)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Other 1
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:58260 Dodelet VC, et al., A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. J Biol Chem. 1999 Nov 5;274(45):31941-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory