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Pald1 Gene Detail
Summary
  • Symbol
    Pald1
  • Name
    phosphatase domain containing, paladin 1
  • Synonyms
    mKIAA1274, paladin, X99384
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351623
    NCBI Gene: 27355
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61155435-61219309 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.19 cM, cytoband B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2082 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351623
 protein coding gene Chr10:61155435-61219325 (-)
129S1/SvImJ ENSMUSG00200028090
 protein coding gene Chr10:57821650-57885529 (-)
A/J ENSMUSG00195025037
 protein coding gene Chr10:58134198-58198075 (-)
AKR/J ENSMUSG00220040308
 protein coding gene Chr10:57826361-57890232 (-)
BALB/cJ ENSMUSG00180022923
 protein coding gene Chr10:58176475-58240351 (-)
C3H/HeJ ENSMUSG00175024996
 protein coding gene Chr10:58028883-58092754 (-)
C57BL/6NJ ENSMUSG00215029587
 protein coding gene Chr10:57774591-57838470 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015365
 protein coding gene Chr10:55813434-55882418 (-)
CAST/EiJ ENSTCUG00005026274
 protein coding gene Chr10:57822896-57886652 (-)
CBA/J ENSMUSG00210030729
 protein coding gene Chr10:57907185-57971058 (-)
DBA/2J ENSMUSG00185039567
 protein coding gene Chr10:58253977-58317854 (-)
FVB/NJ ENSMUSG00205026434
 protein coding gene Chr10:57927595-57991467 (-)
JF1/MsJ ENSUMUG00000021071
 protein coding gene Chr10:59487452-59551743 (-)
LP/J ENSMUSG00230019592
 protein coding gene Chr10:60057074-60120951 (-)
NOD/ShiLtJ ENSMUSG00190032988
 protein coding gene Chr10:58239738-58303611 (-)
NZO/HlLtJ ENSMUSG00225044550
 protein coding gene Chr10:64338030-64401907 (-)
PWK/PhJ ENSLUMG00010021437
 protein coding gene Chr10:57849589-57913811 (-)
SPRET/EiJ ENSMSPG00010025565
 protein coding gene Chr10:59446968-59509478 (-)
WSB/EiJ ENSIUOG00005038463
 protein coding gene Chr10:57810969-57874951 (-)



Homology
more
  • Human Ortholog
    PALD1, phosphatase domain containing paladin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PALD1, phosphatase domain containing paladin 1
  • Synonyms
    KIAA1274, PALD
  • Links
    NCBI Gene ID: 27143
    UniProt: Q9ULE6

  • Chr Location
    10q22.1; chr10:70458485-70668754 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female, but not male, mice homozygous for a knock-out allele exhibit an emphysema-like phenotype associated with increased alveolar air spaces, impaired lung function, and increased lung endothelial cell apoptosis and proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    78
  • cDNA Data
    64
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020092 Ensembl Gene Model | MGI Sequence Detail 63875 C57BL/6J ±  kb
    transcript ENSMUST00000020289 Ensembl | MGI Sequence Detail 4282 Not Applicable  
    polypeptide ENSMUSP00000020289 Ensembl | MGI Sequence Detail 859 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 64
      Primer pair 1
      Other 1
      Antibodies 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 24
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory