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Mrpl39 Gene Detail
Summary
  • Symbol
    Mrpl39
  • Name
    mitochondrial ribosomal protein L39
  • Synonyms
    MRP-L5, Rpml5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351620
    NCBI Gene: 27393
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:84515068-84532261 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 46.92 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    618 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351620
 protein coding gene Chr16:84514464-84532630 (-)
129S1/SvImJ ENSMUSG00200037132
 protein coding gene Chr16:81413925-81432127 (-)
A/J ENSMUSG00195022335
 protein coding gene Chr16:81208420-81226642 (-)
AKR/J ENSMUSG00220017557
 protein coding gene Chr16:81362062-81380241 (-)
BALB/cJ ENSMUSG00180002008
 protein coding gene Chr16:81248838-81266991 (-)
C3H/HeJ ENSMUSG00175014057
 protein coding gene Chr16:81563719-81581939 (-)
C57BL/6NJ ENSMUSG00215017372
 protein coding gene Chr16:81376717-81394885 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020888
 protein coding gene Chr16:79353155-79370424 (-)
CAST/EiJ ENSTCUG00005007273
 protein coding gene Chr16:81025056-81054493 (-)
CBA/J ENSMUSG00210032056
 protein coding gene Chr16:81474310-81492465 (-)
DBA/2J ENSMUSG00185005004
 protein coding gene Chr16:81420340-81438512 (-)
FVB/NJ ENSMUSG00205013782
 protein coding gene Chr16:81236947-81255151 (-)
JF1/MsJ ENSUMUG00000023747
 protein coding gene Chr16:81546242-81575562 (-)
LP/J ENSMUSG00230032467
 protein coding gene Chr16:83973817-83992025 (-)
NOD/ShiLtJ ENSMUSG00190022881
 protein coding gene Chr16:81425703-81443903 (-)
NZO/HlLtJ ENSMUSG00225030875
 protein coding gene Chr16:87104925-87123077 (-)
PWK/PhJ ENSLUMG00010004786
 protein coding gene Chr16:81202015-81231372 (-)
SPRET/EiJ ENSMSPG00010028126
 protein coding gene Chr16:82183132-82200298 (-)
WSB/EiJ ENSIUOG00005016757
 protein coding gene Chr16:81352454-81370644 (-)



Homology
more
  • Human Ortholog
    MRPL39, mitochondrial ribosomal protein L39
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRPL39, mitochondrial ribosomal protein L39
  • Synonyms
    C21orf92, COXPD59, L39mt, L5mt, mL39, MRP-L5, MRPL5, MSTP003, PRED22, PRED66, RPML5
  • Links
    NCBI Gene ID: 54148
    UniProt: Q9NYK5

  • Chr Location
    21q21.3; chr21:25585632-25607859 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MRPL39 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    387 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    69
  • cDNA Data
    73
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27393 NCBI Gene Model | MGI Sequence Detail 17194 C57BL/6J ±  kb
    transcript NM_001384095 RefSeq | MGI Sequence Detail 2627 C57BL/6  
    polypeptide Q9JKF7 UniProt | EBI | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 73
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1889207
    References
    more
    • Summaries
      All 422
      Developmental Gene Expression 3
      Diseases 7
      Gene Ontology 11
      Phenotypes 387
    • Earliest
      J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
    • Latest
      J:391449 Thibodeau J, et al., Loss of cystathionine-beta-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome. Biochem Pharmacol. 2026 Feb 13;247:117815
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory