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Rpl3 Gene Detail
Summary
  • Symbol
    Rpl3
  • Name
    ribosomal protein L3
  • Synonyms
    F2, J1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351605
    NCBI Gene: 27367
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79961993-79967553 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    306 from dbSNP Build 142
  • Strain Annotations
    24
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351605
 protein coding gene Chr15:79961992-79976069 (-)
129S1/SvImJ ENSMUSG00200028420
 protein coding gene Chr18:44941891-44943186 (-)
129S1/SvImJ ENSMUSGG00200054966
 protein coding gene Chr15:77069724-77072161 (-)
A/J ENSMUSGG00195055510
 protein coding gene Chr15:77015261-77017698 (-)
A/J ENSMUSG00195024252
 protein coding gene Chr18:45120520-45121815 (-)
AKR/J ENSMUSG00220020215
 protein coding gene Chr18:45070270-45071565 (-)
AKR/J ENSMUSGG00220054912
 protein coding gene Chr15:77058395-77060832 (-)
BALB/cJ ENSMUSGG00180054975
 protein coding gene Chr15:76892310-76894747 (-)
BALB/cJ ENSMUSG00180007427
 protein coding gene Chr18:45609065-45610360 (-)
C3H/HeJ ENSMUSG00175010481
 protein coding gene Chr18:45121375-45122670 (-)
C3H/HeJ ENSMUSGG00175055145
 protein coding gene Chr15:77203441-77205878 (-)
C57BL/6NJ ENSMUSGG00215055814
 protein coding gene Chr15:76975555-76977992 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020032
 protein coding gene Chr15:74088714-74102767 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210022182
 protein coding gene Chr18:45173108-45174403 (-)
CBA/J ENSMUSGG00210055085
 protein coding gene Chr15:76978581-76981018 (-)
DBA/2J ENSMUSG00185027668
 protein coding gene Chr18:45073352-45074647 (-)
DBA/2J ENSMUSGG00185057955
 protein coding gene Chr15:76988521-76990958 (-)
FVB/NJ ENSMUSGG00205054651
 protein coding gene Chr15:76715819-76718256 (-)
FVB/NJ ENSMUSG00205013758
 protein coding gene Chr18:44554325-44555620 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230024851
 protein coding gene Chr18:47153227-47154522 (-)
LP/J ENSMUSGG00230055873
 protein coding gene Chr15:80318101-80320538 (-)
NOD/ShiLtJ ENSMUSGG00190055107
 protein coding gene Chr15:76995602-76998039 (-)
NOD/ShiLtJ ENSMUSG00190023117
 protein coding gene Chr18:44854966-44856261 (-)
NZO/HlLtJ ENSMUSGG00225055151
 protein coding gene Chr15:80653848-80656285 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RPL3, ribosomal protein L3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL3, ribosomal protein L3
  • Synonyms
    ASC-1, L3, TARBP-B, uL3
  • Links
    NCBI Gene ID: 6122
    UniProt: P39023

  • Chr Location
    22q13.1; chr22:39312870-39320389 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    7
  • Gene trapped
    21
  • Radiation induced
    2
  • Genomic Mutations
    3 involving Rpl3
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    37 strains or lines available
Homozygous null mice exhibit prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    6
  • cDNA Data
    39
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27367 NCBI Gene Model | MGI Sequence Detail 5561 C57BL/6J ±  kb
transcript NR_177964 RefSeq | MGI Sequence Detail 1476 C57BL/6  
polypeptide P27659 UniProt | EBI | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 39
    Primer pair 3

    Microarray probesets 9
References
more
  • Summaries
    All 71
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 11
    Phenotypes 32
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory