About   Help   FAQ
Phlda3 Gene Detail
Summary
  • Symbol
    Phlda3
  • Name
    pleckstrin homology like domain, family A, member 3
  • Synonyms
    TDAG/lpl homolog 1, Tih1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351485
    NCBI Gene: 27280
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:135693857-135696874 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 59.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351485
 protein coding gene Chr1:135693823-135696874 (+)
129S1/SvImJ ENSMUSG00200007967
 protein coding gene Chr1:133308301-133311326 (+)
A/J ENSMUSG00195015156
 protein coding gene Chr1:132380764-132383790 (+)
AKR/J ENSMUSG00220046694
 protein coding gene Chr1:132260439-132263462 (+)
BALB/cJ ENSMUSG00180011009
 protein coding gene Chr1:132921703-132924720 (+)
C3H/HeJ ENSMUSG00175006403
 protein coding gene Chr1:132624863-132627888 (+)
C57BL/6NJ ENSMUSG00215010812
 protein coding gene Chr1:132623542-132626559 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014642
 protein coding gene Chr1:127373405-127376410 (+)
CAST/EiJ ENSTCUG00005034604
 protein coding gene Chr1:131554210-131557234 (+)
CBA/J ENSMUSG00210013858
 protein coding gene Chr1:132555206-132558231 (+)
DBA/2J ENSMUSG00185028121
 protein coding gene Chr1:136931549-136934572 (+)
FVB/NJ ENSMUSG00205002112
 protein coding gene Chr1:131890892-131893917 (+)
JF1/MsJ ENSUMUG00000041898
 protein coding gene Chr1:136055527-136058542 (+)
LP/J ENSMUSG00230037996
 protein coding gene Chr1:136456343-136459360 (+)
NOD/ShiLtJ ENSMUSG00190002619
 protein coding gene Chr1:132569263-132572288 (+)
NZO/HlLtJ ENSMUSG00225017026
 protein coding gene Chr1:140222842-140225865 (+)
PWK/PhJ ENSLUMG00010023727
 protein coding gene Chr1:131680182-131683200 (+)
SPRET/EiJ ENSMSPG00010011534
 protein coding gene Chr1:134483169-134483943 (+)
WSB/EiJ ENSIUOG00005028157
 protein coding gene Chr1:132332118-132335142 (+)



Homology
more
  • Human Ortholog
    PHLDA3, pleckstrin homology like domain family A member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHLDA3, pleckstrin homology like domain family A member 3
  • Synonyms
    TIH1
  • Links
    NCBI Gene ID: 23612
    UniProt: Q9Y5J5

  • Chr Location
    1q32.1; chr1:201464278-201469237 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    14 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving Phlda3
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    8 strains or lines available
Mice homozygous for a knock-out allele exhibit normal embryonic and placental weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    693
  • Tissues
    29
  • cDNA Data
    78
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041801 Ensembl Gene Model | MGI Sequence Detail 3018 C57BL/6J ±  kb
transcript ENSMUST00000038945 Ensembl | MGI Sequence Detail 1435 Not Applicable  
polypeptide ENSMUSP00000040614 Ensembl | MGI Sequence Detail 125 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 81
    cDNA 78
    Primer pair 3
    Antibodies 1

    Microarray probesets 3
References
more
  • Summaries
    All 50
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:338899 Hasapis S, et al., Characterizing the role of Phlda3 in the development of acute toxicity and malignant transformation of hematopoietic cells induced by total-body irradiation in mice. Sci Rep. 2023 Aug 9;13(1):12916
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory