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Plaat1 Gene Detail
Summary
  • Symbol
    Plaat1
  • Name
    phospholipase A and acyltransferase 1
  • Synonyms
    2810012B06Rik, A-C1, Hrasls
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351473
    NCBI Gene: 27281
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:29028447-29049283 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 20.01 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    669 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351473
 protein coding gene Chr16:29027883-29049283 (+)
129S1/SvImJ ENSMUSG00200035808
 protein coding gene Chr16:26038780-26059618 (+)
A/J ENSMUSG00195026909
 protein coding gene Chr16:25593141-25613973 (+)
AKR/J ENSMUSG00220029605
 protein coding gene Chr16:25866584-25887420 (+)
BALB/cJ ENSMUSG00180026675
 protein coding gene Chr16:25815164-25836000 (+)
C3H/HeJ ENSMUSG00175037197
 protein coding gene Chr16:25962867-25983703 (+)
C57BL/6NJ ENSMUSG00215012850
 protein coding gene Chr16:25711427-25732263 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020637
 protein coding gene Chr16:26273475-26294122 (+)
CAST/EiJ ENSTCUG00005031686
 protein coding gene Chr16:26248982-26269722 (+)
CBA/J ENSMUSG00210035166
 protein coding gene Chr16:26004923-26025757 (+)
DBA/2J ENSMUSG00185018649
 protein coding gene Chr16:25920304-25941140 (+)
FVB/NJ ENSMUSG00205013368
 protein coding gene Chr16:25957194-25978029 (+)
JF1/MsJ ENSUMUG00000023983
 protein coding gene Chr16:26103682-26124434 (+)
LP/J ENSMUSG00230031020
 protein coding gene Chr16:28490118-28510954 (+)
NOD/ShiLtJ ENSMUSG00190032459
 protein coding gene Chr16:26109909-26130640 (+)
NZO/HlLtJ ENSMUSG00225039084
 protein coding gene Chr16:31725016-31745852 (+)
PWK/PhJ ENSLUMG00010029127
 protein coding gene Chr16:25942430-25963216 (+)
SPRET/EiJ ENSMSPG00010016278
 protein coding gene Chr16:25905891-25926858 (+)
WSB/EiJ ENSIUOG00005031007
 protein coding gene Chr16:26146802-26167499 (+)



Homology
more
  • Human Ortholog
    PLAAT1, phospholipase A and acyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLAAT1, phospholipase A and acyltransferase 1
  • Synonyms
    A-C1, HRASLS, HRASLS1, H-REV107, HRSL1, HSD28, PLA/AT1, PLAAT-1
  • Links
    NCBI Gene ID: 57110
    UniProt: Q9HDD0

  • Chr Location
    3q29; chr3:193240606-193281426 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show decreased susceptibility to high-fat diet-induced obesity and hepatic steatosis with no increased risk of insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    24
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022525 Ensembl Gene Model | MGI Sequence Detail 20837 C57BL/6J ±  kb
    transcript ENSMUST00000089824 Ensembl | MGI Sequence Detail 2916 Not Applicable  
    polypeptide ENSMUSP00000087257 Ensembl | MGI Sequence Detail 167 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1923613, MGI:6285804
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 7
    • Earliest
      J:58251 Akiyama H, et al., Molecular cloning and biological activity of a novel Ha-Ras suppressor gene predominantly expressed in skeletal muscle, heart, brain, and bone marrow by differential display using clonal mouse EC cells, ATDC5. J Biol Chem. 1999 Nov 5;274(45):32192-7
    • Latest
      J:368159 Hashemi A, et al., Plaat1 deficiency reduces cardiac cardiolipin content and impairs exercise tolerance. J Lipid Res. 2025 May 8;66(6):100822
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory