Azi2 MGI Mouse Gene Detail - MGI:1351332 - 5-azacytidine induced gene 2

Symbol

Azi2
Name

5-azacytidine induced gene 2
Synonyms

AZ2

Feature Type

protein coding gene
IDs

MGI:1351332
NCBI Gene: 27215
Alliance

genome feature page
Transcription Start Sites

18 TSS

Sequence Map

Chr9:117869567-117898862 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 69.86 cM
Mapping Data

3 experiments

SNPs within 2kb

796 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351332	protein coding gene	Chr9:117869510-117898866 (+)
129S1/SvImJ	ENSMUSG00200027751	protein coding gene	Chr9:114999959-115022781 (+)
A/J	ENSMUSG00195026391	protein coding gene	Chr9:114178498-114201346 (+)
AKR/J	ENSMUSG00220018426	protein coding gene	Chr9:114633797-114656374 (+)
BALB/cJ	ENSMUSG00180023284	protein coding gene	Chr9:114715934-114738780 (+)
C3H/HeJ	ENSMUSG00175016820	protein coding gene	Chr9:114959271-114982115 (+)
C57BL/6NJ	ENSMUSG00215014685	protein coding gene	Chr9:114828061-114850929 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032785	protein coding gene	Chr9:113462009-113492356 (+)
CAST/EiJ	ENSTCUG00005015739	protein coding gene	Chr9:114602474-114625098 (+)
CBA/J	ENSMUSG00210038520	protein coding gene	Chr9:114673350-114695882 (+)
DBA/2J	ENSMUSG00185016770	protein coding gene	Chr9:115007537-115030068 (+)
FVB/NJ	ENSMUSG00205014871	protein coding gene	Chr9:114847361-114870206 (+)
JF1/MsJ	ENSUMUG00000039073	protein coding gene	Chr9:114848790-114871562 (+)
LP/J	ENSMUSG00230034615	protein coding gene	Chr9:115128420-115151242 (+)
NOD/ShiLtJ	ENSMUSG00190014312	protein coding gene	Chr9:114584875-114607406 (+)
NZO/HlLtJ	ENSMUSG00225022786	protein coding gene	Chr9:115389942-115412472 (+)
PWK/PhJ	ENSLUMG00010033304	protein coding gene	Chr9:114769709-114792504 (+)
SPRET/EiJ	ENSMSPG00010022777	protein coding gene	Chr9:116451741-116484066 (+)
WSB/EiJ	ENSIUOG00005019547	protein coding gene	Chr9:114071430-114093987 (+)

Human Ortholog

AZI2, 5-azacytidine induced 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AZI2, 5-azacytidine induced 2
Synonyms

AZ2, NAP1, TILP
Links

HGNC:24002

NCBI Gene ID: 64343

UniProt: Q9H6S1
Chr Location

3p24.1; chr3:28315003-28349050 (-) GRCh38

MGI Vertebrate Homology

Azi2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AZI2
Gene Tree

Azi2

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
6 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

4
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired GM-CSF-derived bone marrow-derived dendritic cell differenatiation, cytokine response and ability to stimulate T cells.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

636
Tissues

27
cDNA Data

19
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase azi2

ZFIN azi2

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All Sequences

87
RefSeq

23
UniProt

6
CCDS

CCDS40799.1, CCDS52959.1

Ensembl

ENSMUSG00000039285 (Evidence)
NCBI Gene

27215

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039285	Ensembl Gene Model \| MGI Sequence Detail	29296	C57BL/6J	± kb
transcript	ENSMUST00000044454	Ensembl \| MGI Sequence Detail	3396	Not Applicable
polypeptide	ENSMUSP00000044350	Ensembl \| MGI Sequence Detail	405	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004532 5-azacytidine-induced protein 2

(term hierarchy)
InterPro Domains

IPR051891 TANK-binding kinase 1-binding protein 1/5-azacytidine-induced protein 2

IPR024581 Tbk1/Ikki binding domain

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All nucleic 21

cDNA 21

Microarray probesets 5

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MGI:2146344

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 9
Earliest

J:20478 Hutchison JB, et al., Brain formation of oestrogen in the mouse: sex dimorphism in aromatase development. J Steroid Biochem Mol Biol. 1994 Jun;49(4-6):407-15
Latest

J:250928 Cirilli M, et al., Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Biochim Biophys Acta. 2017 Feb;1861(2):467-476

TSS for Azi2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87606	Chr9:117869543-117869562 (+)	-14 bp
Tssr87607	Chr9:117869577-117869634 (+)	39 bp
Tssr87608	Chr9:117869644-117869651 (+)	81 bp
Tssr87609	Chr9:117869662-117869672 (+)	100 bp
Tssr87610	Chr9:117869676-117869683 (+)	113 bp
Tssr87611	Chr9:117869691-117869698 (+)	128 bp
Tssr87612	Chr9:117869726-117869737 (+)	165 bp
Tssr87613	Chr9:117870226-117870230 (+)	661 bp
Tssr87614	Chr9:117872950-117872988 (+)	3,402 bp
Tssr87615	Chr9:117876456-117876466 (+)	6,894 bp
Tssr87616	Chr9:117878777-117878793 (+)	9,218 bp
Tssr87617	Chr9:117878830-117878841 (+)	9,269 bp
Tssr87618	Chr9:117879058-117879072 (+)	9,498 bp
Tssr87619	Chr9:117879126-117879169 (+)	9,581 bp
Tssr87620	Chr9:117879294-117879299 (+)	9,730 bp
Tssr87622	Chr9:117884016-117884020 (+)	14,451 bp
Tssr87623	Chr9:117888158-117888202 (+)	18,613 bp
Tssr87624	Chr9:117888516-117888534 (+)	18,958 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29