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Chaf1a Gene Detail
Summary
  • Symbol
    Chaf1a
  • Name
    chromatin assembly factor 1, subunit A
  • Synonyms
    CAF-1, p150
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351331
    NCBI Gene: 27221
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56347404-56375027 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.13 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    650 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351331
 protein coding gene Chr17:56347404-56379289 (+)
129S1/SvImJ ENSMUSG00200016429
 protein coding gene Chr17:51622515-51652365 (+)
A/J ENSMUSG00195006799
 protein coding gene Chr17:53009945-53039788 (+)
AKR/J ENSMUSG00220012188
 protein coding gene Chr17:52059389-52089226 (+)
BALB/cJ ENSMUSG00180006021
 protein coding gene Chr17:52767577-52797419 (+)
C3H/HeJ ENSMUSG00175007109
 protein coding gene Chr17:52083648-52113486 (+)
C57BL/6NJ ENSMUSG00215007948
 protein coding gene Chr17:51697769-51727609 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021761
 protein coding gene Chr17:52630603-52658026 (+)
CAST/EiJ ENSTCUG00005017774
 protein coding gene Chr17:52816627-52846522 (+)
CBA/J ENSMUSG00210026612
 protein coding gene Chr17:51850708-51880545 (+)
DBA/2J ENSMUSG00185009048
 protein coding gene Chr17:54720570-54750407 (+)
FVB/NJ ENSMUSG00205006905
 protein coding gene Chr17:52398204-52428052 (+)
JF1/MsJ ENSUMUG00000024215
 protein coding gene Chr17:54398536-54428248 (+)
LP/J ENSMUSG00230024599
 protein coding gene Chr17:55699954-55729795 (+)
NOD/ShiLtJ ENSMUSG00190009358
 protein coding gene Chr17:51853304-51883260 (+)
NZO/HlLtJ ENSMUSG00225042121
 protein coding gene Chr17:57983783-58013620 (+)
PWK/PhJ ENSLUMG00010008886
 protein coding gene Chr17:51659486-51689313 (+)
SPRET/EiJ ENSMSPG00010004908
 protein coding gene Chr17:51976699-52004602 (+)
WSB/EiJ ENSIUOG00005022117
 protein coding gene Chr17:52760069-52789896 (+)



Homology
more
  • Human Ortholog
    CHAF1A, chromatin assembly factor 1 subunit A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHAF1A, chromatin assembly factor 1 subunit A
  • Synonyms
    CAF-1, CAF1, CAF1B, CAF1P150, P150
  • Links
    NCBI Gene ID: 10036
    UniProt: Q13111

  • Chr Location
    19p13.3; chr19:4402617-4450830 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human CHAF1A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation in this gene display lethality before implantation, embryonic growth arrest, and abnormal heterochromatin morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    9
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27221 NCBI Gene Model | MGI Sequence Detail 27624 C57BL/6J ±  kb
transcript NM_013733 RefSeq | MGI Sequence Detail 3321 C57BL/6  
polypeptide Q9QWF0 UniProt | EBI | MGI Sequence Detail 911 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005402 chromatin assembly factor 1 subunit A
    (term hierarchy)
  • PDB
    1S4Z
  • InterPro Domains
    IPR021644 Chromatin assembly factor 1 p150 subunit, acidic region
    IPR022043 Chromatin assembly factor 1 subunit A, dimerization domain
    IPR029105 Chromatin assembly factor 1 subunit p150, C-terminal
    IPR029091 Chromatin assembly factor 1 subunit p150, N-terminal
  • GlyGen
    Q9QWF0 3 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146952, MGI:2146957
References
more
  • Summaries
    All 48
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:58148 Murzina N, et al., Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins. Mol Cell. 1999 Oct;4(4):529-40
  • Latest
    J:384906 Mori M, et al., Aging-associated reduction of chromosomal histones in mammalian oocytes. Genes Cells. 2024 Oct;29(10):808-819
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory