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Gimap4 Gene Detail
Summary
  • Symbol
    Gimap4
  • Name
    GTPase, IMAP family member 4
  • Synonyms
    E430007K16Rik, Ian1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349656
    NCBI Gene: 107526
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:48661483-48668994 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 23.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    289 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349656
 protein coding gene Chr6:48661453-48668996 (+)
129S1/SvImJ ENSMUSG00200004944
 protein coding gene Chr6:45567175-45574686 (+)
A/J ENSMUSG00195006580
 protein coding gene Chr6:45338092-45345601 (+)
AKR/J ENSMUSG00220003424
 protein coding gene Chr6:45049230-45056753 (+)
BALB/cJ ENSMUSG00180019955
 protein coding gene Chr6:45652644-45660168 (+)
C3H/HeJ ENSMUSG00175015437
 protein coding gene Chr6:45414266-45421787 (+)
C57BL/6NJ ENSMUSG00215006863
 protein coding gene Chr6:45612232-45619743 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028349
 protein coding gene Chr6:43103695-43111871 (+)
CAST/EiJ ENSTCUG00005004196
 protein coding gene Chr6:44926123-44933623 (+)
CBA/J ENSMUSG00210017995
 protein coding gene Chr6:45459123-45466643 (+)
DBA/2J ENSMUSG00185012576
 protein coding gene Chr6:46040815-46048335 (+)
FVB/NJ ENSMUSG00205021097
 protein coding gene Chr6:45705267-45712790 (+)
JF1/MsJ ENSUMUG00000007850
 protein coding gene Chr6:45401223-45408724 (+)
LP/J ENSMUSG00230016866
 protein coding gene Chr6:47064283-47071794 (+)
NOD/ShiLtJ ENSMUSG00190028597
 protein coding gene Chr6:45377330-45384839 (+)
NZO/HlLtJ ENSMUSG00225018300
 protein coding gene Chr6:49100838-49108349 (+)
PWK/PhJ ENSLUMG00010020343
 protein coding gene Chr6:45035525-45043029 (+)
SPRET/EiJ ENSMSPG00010009392
 protein coding gene Chr6:45659284-45666772 (+)
WSB/EiJ ENSIUOG00005025550
 protein coding gene Chr6:45675120-45682636 (+)



Homology
more
  • Human Ortholog
    GIMAP4, GTPase, IMAP family member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GIMAP4, GTPase, IMAP family member 4
  • Synonyms
    IAN-1, IAN1, IMAP4, MSTP062
  • Links
    NCBI Gene ID: 55303
    UniProt: Q9NUV9

  • Chr Location
    7q36.1; chr7:150567242-150573962 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show no detectable alterations in T-cell development, selection and activation; however, mutant T cells exhibit a delay in the execution of programmed cell death induced by intrinsic stimuli downstream of caspase-3 activation and phosphatidylserine exposure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    621
  • Tissues
    15
  • cDNA Data
    12
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054435 Ensembl Gene Model | MGI Sequence Detail 7512 C57BL/6J ±  kb
transcript ENSMUST00000090070 Ensembl | MGI Sequence Detail 1804 Not Applicable  
polypeptide ENSMUSP00000087524 Ensembl | MGI Sequence Detail 328 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 2
    cDNA 12

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141562
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:58144 Poirier GM, et al., Immune-associated nucleotide-1 (IAN-1) is a thymic selection marker and defines a novel gene family conserved in plants. J Immunol. 1999 Nov 1;163(9):4960-9
  • Latest
    J:267911 Timmermans S, et al., Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. JCI Insight. 2018 Jul 12;3(13)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory