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Med14 Gene Detail
Summary
  • Symbol
    Med14
  • Name
    mediator complex subunit 14
  • Synonyms
    9930001L01Rik, Crsp2, ENSMUSG00000073278, LOC270579, ORF1, Trap170
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349442
    NCBI Gene: 26896
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:12541608-12628312 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 7.52 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1735 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349442
 protein coding gene ChrX:12541607-12628813 (-)
129S1/SvImJ ENSMUSG00200030990
 protein coding gene ChrX:7285389-7372096 (-)
A/J ENSMUSG00195038943
 protein coding gene ChrX:7257691-7344390 (-)
AKR/J ENSMUSG00220033195
 protein coding gene ChrX:6794418-6881130 (-)
BALB/cJ ENSMUSG00180028267
 protein coding gene ChrX:7257144-7343846 (-)
C3H/HeJ ENSMUSG00175030893
 protein coding gene ChrX:7282300-7368998 (-)
C57BL/6NJ ENSMUSG00215040518
 protein coding gene ChrX:7920326-8007029 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032939
 protein coding gene ChrX:6526054-6607740 (-)
CAST/EiJ ENSTCUG00005029592
 protein coding gene ChrX:7253007-7339729 (-)
CBA/J ENSMUSG00210038071
 protein coding gene ChrX:7331593-7418280 (-)
DBA/2J ENSMUSG00185035734
 protein coding gene ChrX:13920813-14007512 (-)
FVB/NJ ENSMUSG00205030747
 protein coding gene ChrX:6993342-7079848 (-)
JF1/MsJ ENSUMUG00000026126
 protein coding gene ChrX:27770706-27857318 (-)
LP/J ENSMUSG00230031858
 protein coding gene ChrX:18503929-18590630 (-)
NOD/ShiLtJ ENSMUSG00190032040
 protein coding gene ChrX:7280778-7367476 (-)
NZO/HlLtJ ENSMUSG00225033219
 protein coding gene ChrX:23711292-23797997 (-)
PWK/PhJ ENSLUMG00010029538
 protein coding gene ChrX:7158447-7245956 (-)
SPRET/EiJ ENSMSPG00010022957
 protein coding gene ChrX:8124582-8211001 (-)
WSB/EiJ ENSIUOG00005016102
 protein coding gene ChrX:3965637-4052104 (-)



Homology
more
  • Human Ortholog
    MED14, mediator complex subunit 14
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED14, mediator complex subunit 14
  • Synonyms
    CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170
  • Links
    NCBI Gene ID: 9282
    UniProt: O60244

  • Chr Location
    Xp11.4; chrX:40648305-40736159 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 images
    7 phenotype references
Male chimeras hemizygous for a gene trapped allele appear normal at E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    157
  • cDNA Data
    22
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064127 Ensembl Gene Model | MGI Sequence Detail 86705 C57BL/6J ±  kb
transcript ENSMUST00000096495 Ensembl | MGI Sequence Detail 6963 Not Applicable  
polypeptide ENSMUSP00000094239 Ensembl | MGI Sequence Detail 1459 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010286 mediator of RNA polymerase II transcription subunit 14
    (term hierarchy)
  • PDB
    6W1S, 8T1I, 8T1L
  • InterPro Domains
    IPR013947 Mediator complex, subunit Med14
    IPR055122 Mediator complex subunit MED14, N-terminal
    IPR056877 Mediator of RNA polymerase II transcription subunit 14, C-terminal domain
    IPR055113 Mediator of RNA polymerase II transcription subunit 14, RM2
    IPR056879 Mediator of RNA polymerase II transcription subunit 14, RM3
    IPR056878 Mediator of RNA polymerase II transcription subunit 14, RM5
    IPR055114 Mediator of RNA polymerase II transcription subunit 14, RM6
    IPR055107 Mediator of RNA polymerase II transcription subunit 14, RM8
  • GlyGen
    A2ABV5 2 sites
Molecular
Reagents
less
  • All nucleic 26
    Genomic 1
    cDNA 22
    Primer pair 3
    Antibodies 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:2147974, MGI:2685487, MGI:3641973
References
more
  • Summaries
    All 54
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 7
  • Earliest
    J:58086 Takada S, et al., Detection and cloning of an X-linked locus associated with a NotI site that is not methylated on mouse inactivated X chromosome by the RLGS-M method. Genomics. 1999 Oct 1;61(1):92-100
  • Latest
    J:379748 Zhu S, et al., The essential role of MED27 in stabilizing the mediator complex for cardiac development and function. Life Sci. 2024 Nov 1;356:123020
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory