Map3k5 MGI Mouse Gene Detail - MGI:1346876 - mitogen-activated protein kinase kinase kinase 5

Symbol

Map3k5
Name

mitogen-activated protein kinase kinase kinase 5
Synonyms

7420452D20Rik, ASK, ASK1, Mekk5

Feature Type

protein coding gene
IDs

MGI:1346876
NCBI Gene: 26408
Alliance

genome feature page
Transcription Start Sites

16 TSS

Sequence Map

Chr10:19810218-20018499 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 9.35 cM
Mapping Data

2 experiments

SNPs within 2kb

6029 from dbSNP Build 142
Strain Annotations

27

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346876	protein coding gene	Chr10:19809847-20018499 (+)
129S1/SvImJ	ENSMUSGG00200054667	protein coding gene	Chr10:16867502-16890619 (+)
129S1/SvImJ	ENSMUSG00200009527	protein coding gene	Chr10:16949347-16966913 (+)
A/J	ENSMUSGG00195055157	protein coding gene	Chr10:16879529-16902647 (+)
A/J	ENSMUSG00195006243	protein coding gene	Chr10:16961383-16978951 (+)
AKR/J	ENSMUSG00220010042	protein coding gene	Chr10:16870954-16888733 (+)
AKR/J	ENSMUSGG00220054463	protein coding gene	Chr10:16789123-16812261 (+)
BALB/cJ	ENSMUSG00180014818	protein coding gene	Chr10:17085604-17103172 (+)
BALB/cJ	ENSMUSGG00180055165	protein coding gene	Chr10:17003750-17026871 (+)
C3H/HeJ	ENSMUSGG00175054595	protein coding gene	Chr10:17023561-17046682 (+)
C3H/HeJ	ENSMUSG00175019822	protein coding gene	Chr10:17105418-17122982 (+)
C57BL/6NJ	ENSMUSG00215003349	protein coding gene	Chr10:16912865-16930643 (+)
C57BL/6NJ	ENSMUSGG00215055243	protein coding gene	Chr10:16831037-16854180 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015154	protein coding gene	Chr10:15996665-16192173 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210015261	protein coding gene	Chr10:17042912-17060687 (+)
CBA/J	ENSMUSGG00210054750	protein coding gene	Chr10:16961082-16984219 (+)
DBA/2J	ENSMUSG00185006424	protein coding gene	Chr10:17027559-17045126 (+)
DBA/2J	ENSMUSGG00185057476	protein coding gene	Chr10:16945708-16968825 (+)
FVB/NJ	ENSMUSG00205014718	protein coding gene	Chr10:16946991-16964544 (+)
FVB/NJ	ENSMUSGG00205054527	protein coding gene	Chr10:16863986-16887112 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSGG00230055670	protein coding gene	Chr10:18601633-18624751 (+)
LP/J	ENSMUSG00230015666	protein coding gene	Chr10:18683486-18701052 (+)
NOD/ShiLtJ	ENSMUSGG00190054501	protein coding gene	Chr10:16935748-16958871 (+)
NOD/ShiLtJ	ENSMUSG00190010565	protein coding gene	Chr10:17018746-17036298 (+)
NZO/HlLtJ	ENSMUSGG00225055646	protein coding gene	Chr10:23087142-23110276 (+)
NZO/HlLtJ	ENSMUSG00225030141	protein coding gene	Chr10:23168966-23186736 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010010059	protein coding gene	Chr10:17329498-17536970 (+)
WSB/EiJ	no annotation

Human Ortholog

MAP3K5, mitogen-activated protein kinase kinase kinase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP3K5, mitogen-activated protein kinase kinase kinase 5
Synonyms

ASK1, MAPKKK5, MEKK5
Links

HGNC:6857

NCBI Gene ID: 4217

UniProt: Q99683
Chr Location

6q23.3; chr6:136557034-136793097 (-) GRCh38

MGI Vertebrate Homology

Map3k5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP3K5
Gene Tree

Map3k5

Diseases

1 with human MAP3K5 associations

				Human Disease	Mouse Models
				Huntington's disease IDs Huntington's disease DOID:12858 ICD10CM:G10 ICD9CM_2006:333.4 ICD9CM:333.4 KEGG:05016 MESH:D006816 NCI:C82342 OMIM:143100 UMLS_CUI:C0020179

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

7 phenotypes from 1 allele in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
74 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Spontaneous

1
Targeted

6
Genomic Mutations

2 involving Map3k5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice are overtly normal, however apoptosis abnormalities are evident in cultured cells and after induced heart damage.

less

All GO Annotations

103
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

966
Tissues

261
cDNA Data

35
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MAP3K5

Xenbase map3k5

ZFIN map3k5

less

All Sequences

58
RefSeq

4
UniProt

7
CCDS

CCDS35857.1

Ensembl

ENSMUSG00000071369 (Evidence)
NCBI Gene

26408

			Length	Strain/Species	Flank
genomic	ENSMUSG00000071369	Ensembl Gene Model \| MGI Sequence Detail	208282	C57BL/6J	± kb
transcript	ENSMUST00000095806	Ensembl \| MGI Sequence Detail	5450	Not Applicable
polypeptide	ENSMUSP00000093485	Ensembl \| MGI Sequence Detail	1380	Not Applicable

less

UniProt

7 Sequences
Protein Ontology

PR:000010138 mitogen-activated protein kinase kinase kinase 5

(term hierarchy)
EC

2.7.11.1, 2.7.11.25
InterPro Domains

IPR046872 MAP3K, deoxyribohydrolase domain

IPR046873 MAP3K, HisK-N-like globin domain

IPR043969 MAP3K, PH domain

IPR025136 MAP3K, TRAFs-binding domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR013761 Sterile alpha motif/pointed domain superfamily
GlyGen

O35099 2 sites, 1 O-linked glycan (2 sites)

less

All nucleic 39

cDNA 36

Primer pair 3

Antibodies 6

Microarray probesets 4

less

MGI:1101761, MGI:2445207

Summaries

All 200

Developmental Gene Expression 13

Gene Ontology 19

Phenotypes 74
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:386239 Crespo-Masip M, et al., ASK1 limits kidney glucose reabsorption, growth, and mid-late proximal tubule KIM-1 induction when diabetes and Western diet are combined with SGLT2 inhibition. Am J Physiol Renal Physiol. 2025 May 1;328(5):F662-F675

TSS for Map3k5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92555	Chr10:19809303-19809312 (+)	-910 bp
Tssr3151	Chr10:19809325-19809337 (+)	-887 bp
Tssr92556	Chr10:19809344-19809359 (+)	-866 bp
Tssr92557	Chr10:19809361-19809371 (+)	-852 bp
Tssr92558	Chr10:19809433-19809444 (+)	-779 bp
Tssr92559	Chr10:19809670-19809699 (+)	-533 bp
Tssr92560	Chr10:19809816-19809851 (+)	-384 bp
Tssr92561	Chr10:19809926-19809944 (+)	-283 bp
Tssr92562	Chr10:19809980-19810032 (+)	-212 bp
Tssr92563	Chr10:19810038-19810063 (+)	-167 bp
Tssr3152	Chr10:19815227-19815238 (+)	5,015 bp
Tssr3153	Chr10:19815267-19815276 (+)	5,054 bp
Tssr92564	Chr10:19832863-19832869 (+)	22,648 bp
Tssr92565	Chr10:19886104-19886107 (+)	75,888 bp
Tssr92566	Chr10:19980610-19980629 (+)	170,402 bp
Tssr92567	Chr10:20017628-20017634 (+)	207,413 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24