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Fyb1 Gene Detail
Summary
  • Symbol
    Fyb1
  • Name
    FYN binding protein 1
  • Synonyms
    ADAP, B630013F22Rik, Fyb, FYB-120/130
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346327
    NCBI Gene: 23880
  • Alliance
  • Transcription Start Sites
    57 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:6552334-6692794 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 3.19 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4011 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346327
protein coding gene Chr15:6552280-6695089 (+)
129S1/SvImJ ENSMUSG00200030880
protein coding gene Chr15:3527615-3668068 (+)
A/J ENSMUSG00195009401
protein coding gene Chr15:3445004-3585476 (+)
AKR/J ENSMUSG00220021045
protein coding gene Chr15:3324410-3461212 (+)
BALB/cJ ENSMUSG00180030885
protein coding gene Chr15:3422121-3562577 (+)
C3H/HeJ ENSMUSG00175029822
protein coding gene Chr15:3582317-3722761 (+)
C57BL/6NJ ENSMUSG00215015603
protein coding gene Chr15:3435468-3575940 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019641
protein coding gene Chr15:3154457-3234702 (+)
CAST/EiJ ENSTCUG00005025094
protein coding gene Chr15:3514782-3650082 (+)
CBA/J ENSMUSG00210024919
protein coding gene Chr15:3567279-3707723 (+)
DBA/2J ENSMUSG00185031459
protein coding gene Chr15:3520339-3660791 (+)
FVB/NJ ENSMUSG00205023395
protein coding gene Chr15:3442965-3583453 (+)
JF1/MsJ ENSUMUG00000017142
protein coding gene Chr15:3560642-3714304 (+)
LP/J ENSMUSG00230019085
protein coding gene Chr15:7020859-7161304 (+)
NOD/ShiLtJ ENSMUSG00190009425
protein coding gene Chr15:3509885-3650337 (+)
NZO/HlLtJ ENSMUSG00225034063
protein coding gene Chr15:7272758-7413200 (+)
PWK/PhJ ENSLUMG00010034369
protein coding gene Chr15:3594535-3740495 (+)
SPRET/EiJ ENSMSPG00010029674
protein coding gene Chr15:3621798-3758982 (+)
WSB/EiJ ENSIUOG00005028517
protein coding gene Chr15:3425783-3566276 (+)



Homology
more
  • Human Ortholog
    FYB1, FYN binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FYB1, FYN binding protein 1
  • Synonyms
    ADAP, FYB, PRO0823, SLAP-130, SLAP130, THC3
  • Links
    NCBI Gene ID: 2533
    UniProt: O15117

  • Chr Location
    5p13.1; chr5:39105252-39274528 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human FYB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased T cell proliferation, thymocytes and platelet counts and decreased TCR-stimulated leukocyte adhesion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022148 Ensembl Gene Model | MGI Sequence Detail 140461 C57BL/6J ±  kb
    transcript ENSMUST00000090461 Ensembl | MGI Sequence Detail 2669 Not Applicable  
    polypeptide ENSMUSP00000087947 Ensembl | MGI Sequence Detail 819 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 197
      cDNA 197

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2443545, MGI:7525417
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 1
      Gene Ontology 12
      Phenotypes 45
    • Earliest
      J:41750 da Silva AJ, et al., Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7493-8
    • Latest
      J:391286 Lu J, et al., The ADAP-TRIM21-ZEB2 axis regulates CD8(+) T cell effector expansion and central memory-like differentiation. iScience. 2026 Aug 21;29(8):117016

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory