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Tshz1 Gene Detail
Summary
  • Symbol
    Tshz1
  • Name
    teashirt zinc finger family member 1
  • Synonyms
    5730407I04Rik, D18Bwg1409e, Mtsh1, NY-CO-33, Sdccag33, teashirt1, Tsh1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346031
    NCBI Gene: 110796
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:84029752-84105831 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 57.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1708 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346031
 protein coding gene Chr18:84029752-84105833 (-)
129S1/SvImJ ENSMUSG00200015335
 protein coding gene Chr18:81265690-81340410 (-)
A/J ENSMUSG00195001287
 protein coding gene Chr18:81340150-81415001 (-)
AKR/J ENSMUSG00220016583
 protein coding gene Chr18:81256016-81330779 (-)
BALB/cJ ENSMUSG00180002481
 protein coding gene Chr18:81906890-81981746 (-)
C3H/HeJ ENSMUSG00175018678
 protein coding gene Chr18:81453973-81528806 (-)
C57BL/6NJ ENSMUSG00215017726
 protein coding gene Chr18:80823808-80898651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022447
 protein coding gene Chr18:80108487-80183674 (-)
CAST/EiJ ENSTCUG00005027883
 protein coding gene Chr18:80367598-80442820 (-)
CBA/J ENSMUSG00210017818
 protein coding gene Chr18:81400270-81475104 (-)
DBA/2J ENSMUSG00185004174
 protein coding gene Chr18:81302742-81377587 (-)
FVB/NJ ENSMUSG00205013193
 protein coding gene Chr18:80709295-80784153 (-)
JF1/MsJ ENSUMUG00000015322
 protein coding gene Chr18:81159174-81234464 (-)
LP/J ENSMUSG00230016369
 protein coding gene Chr18:83354604-83429298 (-)
NOD/ShiLtJ ENSMUSG00190003269
 protein coding gene Chr18:81132808-81207573 (-)
NZO/HlLtJ ENSMUSG00225023416
 protein coding gene Chr18:83236845-83311616 (-)
PWK/PhJ ENSLUMG00010003952
 protein coding gene Chr18:81566269-81641430 (-)
SPRET/EiJ ENSMSPG00010001244
 protein coding gene Chr18:81935561-82009897 (-)
WSB/EiJ ENSIUOG00005007601
 protein coding gene Chr18:80752556-80827343 (-)



Homology
more
  • Human Ortholog
    TSHZ1, teashirt zinc finger homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSHZ1, teashirt zinc finger homeobox 1
  • Synonyms
    CAA, NY-CO-33, SDCCAG33, TSH1
  • Links
    NCBI Gene ID: 10194
    UniProt: Q6ZSZ6

  • Chr Location
    18q22.3; chr18:75210755-75289950 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 4 alleles in 5 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die shortly after birth of respiratory distress, have defects in soft palate formation, have altered axial skeleton and have middle ear defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1000
  • Tissues
    129
  • cDNA Data
    84
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046982 Ensembl Gene Model | MGI Sequence Detail 76080 C57BL/6J ±  kb
    transcript ENSMUST00000060303 Ensembl | MGI Sequence Detail 5656 Not Applicable  
    polypeptide ENSMUSP00000089388 Ensembl | MGI Sequence Detail 1084 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      cDNA 85
      Primer pair 4
      Other 3
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33960, MGI:106268, MGI:1917748
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 40
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:367404 Sun Q, et al., Dynorphin modulates reward-seeking actions through a pallido-amygdala cholinergic circuit. Neuron. 2025 Apr 8;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory