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Mab21l2 Gene Detail
Summary
  • Symbol
    Mab21l2
  • Name
    mab-21-like 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346022
    NCBI Gene: 23937
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:86453357-86455590 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 37.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346022
 protein coding gene Chr3:86452888-86455590 (-)
129S1/SvImJ ENSMUSG00200036941
 protein coding gene Chr3:83279692-83283059 (-)
A/J ENSMUSG00195051822
 protein coding gene Chr3:83305850-83309240 (-)
AKR/J ENSMUSG00220044659
 protein coding gene Chr3:83252668-83256073 (-)
BALB/cJ ENSMUSG00180047354
 protein coding gene Chr3:83422257-83425662 (-)
C3H/HeJ ENSMUSG00175037795
 protein coding gene Chr3:83232498-83235886 (-)
C57BL/6NJ ENSMUSG00215048705
 protein coding gene Chr3:83694903-83698306 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025127
 protein coding gene Chr3:79295623-79298672 (-)
CAST/EiJ ENSTCUG00005001768
 protein coding gene Chr3:82763971-82766730 (-)
CBA/J ENSMUSG00210045992
 protein coding gene Chr3:83376761-83380149 (-)
DBA/2J ENSMUSG00185051915
 protein coding gene Chr3:83511108-83514511 (-)
FVB/NJ ENSMUSG00205006169
 protein coding gene Chr3:82342864-82346267 (-)
JF1/MsJ ENSUMUG00000022581
 protein coding gene Chr3:83067154-83070569 (-)
LP/J ENSMUSG00230033200
 protein coding gene Chr3:85500083-85502785 (-)
NOD/ShiLtJ ENSMUSG00190030134
 protein coding gene Chr3:83792375-83795776 (-)
NZO/HlLtJ ENSMUSG00225006347
 protein coding gene Chr3:88242959-88245661 (-)
PWK/PhJ ENSLUMG00010047799
 protein coding gene Chr3:83154624-83158045 (-)
SPRET/EiJ ENSMSPG00010046556
 protein coding gene Chr3:83964634-83967394 (-)
WSB/EiJ ENSIUOG00005049871
 protein coding gene Chr3:83762421-83765181 (-)



Homology
more
  • Human Ortholog
    MAB21L2, mab-21 like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAB21L2, mab-21 like 2
  • Synonyms
    MCOPS14, MCSKS14
  • Links
    NCBI Gene ID: 10586
    UniProt: Q9Y586

  • Chr Location
    4q31.3; chr4:150582151-150584693 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MAB21L2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in omphalocele and defects in ventral body wall formation resulting in death at mid-gestation. Mutants have impaired development of the retina and lens.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    178
  • cDNA Data
    44
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23937 NCBI Gene Model | MGI Sequence Detail 2234 C57BL/6J ±  kb
    transcript NM_011839 RefSeq | MGI Sequence Detail 2252 C57BL/6  
    polypeptide Q8BPP1 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 1
      cDNA 46
      Primer pair 1
      Other 5

      Microarray probesets 3
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:57575 Wong RL, et al., Genomic cloning and chromosomal localization of the mouse Mab21l2 locus. Cytogenet Cell Genet. 1999;86(1):21-4
    • Latest
      J:364519 Bonnelykke TH, et al., Notch3 is an asymmetric gene and a modifier of heart looping defects in Nodal mouse mutants. PLoS Biol. 2025 Mar;23(3):e3002598
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory