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Arhgef28 Gene Detail
Summary
  • Symbol
    Arhgef28
  • Name
    Rho guanine nucleotide exchange factor 28
  • Synonyms
    9230110L08Rik, D13Bwg1089e, p190RhoGEF, Rgnef, RhoGEF, Rho specific exchange factor, RIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346016
    NCBI Gene: 110596
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:98035977-98342947 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 51.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9366 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346016
 protein coding gene Chr13:98035105-98343183 (-)
129S1/SvImJ ENSMUSGG00200054856
 protein coding gene Chr13:92605267-92722132 (-)
A/J ENSMUSGG00195055368
 protein coding gene Chr13:93099534-93216385 (-)
AKR/J ENSMUSGG00220054384
 protein coding gene Chr13:91566541-91683339 (-)
BALB/cJ ENSMUSGG00180055450
 protein coding gene Chr13:93634831-93751719 (-)
C3H/HeJ ENSMUSGG00175054851
 protein coding gene Chr13:93801806-93918680 (-)
C57BL/6NJ ENSMUSGG00215055474
 protein coding gene Chr13:93685740-93802703 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018817
 protein coding gene Chr13:91546427-91843353 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054941
 protein coding gene Chr13:93128147-93244939 (-)
DBA/2J ENSMUSGG00185057649
 protein coding gene Chr13:96788885-96905679 (-)
FVB/NJ ENSMUSGG00205054326
 protein coding gene Chr13:92589453-92706324 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055593
 protein coding gene Chr13:106789847-106906696 (-)
NOD/ShiLtJ ENSMUSGG00190054787
 protein coding gene Chr13:93459418-93576278 (-)
NZO/HlLtJ ENSMUSGG00225055419
 protein coding gene Chr13:99315007-99431867 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010008030
 protein coding gene Chr13:93828812-94132934 (-)
WSB/EiJ ENSIUOGG00005054184
 protein coding gene Chr13:92476263-92593027 (-)



Homology
more
  • Human Ortholog
    ARHGEF28, Rho guanine nucleotide exchange factor 28
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF28, Rho guanine nucleotide exchange factor 28
  • Synonyms
    p190RHOGEF, RGNEF, RIP2
  • Links
    NCBI Gene ID: 64283
    UniProt: Q8N1W1

  • Chr Location
    5q13.2; chr5:73625757-73942391 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    4 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are born at lower than expected Mendelian ratios and exhibit a reduction in overall size that becomes negligible by 8 weeks of age. Mouse embryonic fibroblasts display defects in cell migration and focal adhesion formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    639
  • Tissues
    26
  • cDNA Data
    12
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021662 Ensembl Gene Model | MGI Sequence Detail 306971 C57BL/6J ±  kb
    transcript ENSMUST00000109426 Ensembl | MGI Sequence Detail 5387 Not Applicable  
    polypeptide ENSMUSP00000105053 Ensembl | MGI Sequence Detail 1700 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 14
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-34027, MGI:106335, MGI:1349443, MGI:1925160, MGI:2145208
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory