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Pcbp1 Gene Detail
Summary
  • Symbol
    Pcbp1
  • Name
    poly(rC) binding protein 1
  • Synonyms
    [a]CP-1, hnRNP E1, WBP17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345635
    NCBI Gene: 23983
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:86501462-86503171 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.72 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345635
 protein coding gene Chr6:86501462-86503303 (-)
129S1/SvImJ ENSMUSG00200042922
 protein coding gene Chr6:83461752-83463583 (-)
A/J ENSMUSG00195036310
 protein coding gene Chr6:83145867-83147698 (-)
AKR/J ENSMUSG00220026331
 protein coding gene Chr6:82057430-82059257 (-)
BALB/cJ ENSMUSG00180014593
 protein coding gene Chr6:83530654-83532481 (-)
C3H/HeJ ENSMUSG00175035209
 protein coding gene Chr6:93881669-93883500 (+)
C57BL/6NJ ENSMUSG00215017367
 protein coding gene Chr6:83527351-83529181 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028598
 protein coding gene Chr6:82603745-82605584 (-)
CAST/EiJ ENSTCUG00005016736
 protein coding gene Chr6:83473080-83474917 (-)
CBA/J ENSMUSG00210035531
 protein coding gene Chr6:83336938-83338770 (-)
DBA/2J ENSMUSG00185037600
 protein coding gene Chr6:83884099-83885930 (-)
FVB/NJ ENSMUSG00205022252
 protein coding gene Chr6:82514980-82516811 (-)
JF1/MsJ ENSUMUG00000031886
 protein coding gene Chr6:82834470-82836299 (-)
LP/J ENSMUSG00230048474
 protein coding gene Chr6:85018347-85020178 (-)
NOD/ShiLtJ ENSMUSG00190038350
 protein coding gene Chr6:82960705-82962536 (-)
NZO/HlLtJ ENSMUSG00225019028
 protein coding gene Chr6:86983825-86985656 (-)
PWK/PhJ ENSLUMG00010031598
 protein coding gene Chr6:82246952-82248782 (-)
SPRET/EiJ ENSMSPG00010040145
 protein coding gene Chr6:84389868-84391698 (-)
WSB/EiJ ENSIUOG00005027387
 protein coding gene Chr6:83881096-83882925 (-)



Homology
more
  • Human Ortholog
    PCBP1, poly(rC) binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCBP1, poly(rC) binding protein 1
  • Synonyms
    HEL-S-85, hnRNP-E1, hnRNP-X, HNRPE1, HNRPX
  • Links
    NCBI Gene ID: 5093
    UniProt: Q15365

  • Chr Location
    2p13.3; chr2:70087477-70089203 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit reduced body weight. Mice homozygous for the allele exhibit embryonic lethality between E3.5 and E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    245
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23983 NCBI Gene Model | MGI Sequence Detail 1710 C57BL/6J ±  kb
    transcript NM_011865 RefSeq | MGI Sequence Detail 1710 C57BL/6  
    polypeptide P60335 UniProt | EBI | MGI Sequence Detail 356 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 246
      Genomic 1
      cDNA 245

      Microarray probesets 3
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 6
      Gene Ontology 15
      Phenotypes 20
    • Earliest
      J:36107 Funke B, et al., The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins. Nucleic Acids Res. 1996 Oct 1;24(19):3821-8
    • Latest
      J:387436 Ji X, et al., RNA binding protein PCBP1 functions in the Endothelial-to-Hematopoietic transition during hematopoietic stem cell formation. Exp Hematol. 2026 Jun 10;:105470
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory