Slc11a2 MGI Mouse Gene Detail - MGI:1345279 - solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

Symbol

Slc11a2
Name

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Synonyms

DCT1, DMT1, microcytic anemia, viable anaemia, Nramp2, van

Feature Type

protein coding gene
IDs

MGI:1345279
NCBI Gene: 18174
Alliance

genome feature page
Transcription Start Sites

15 TSS

Sequence Map

Chr15:100285779-100322090 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.29 cM
Mapping Data

11 experiments

SNPs within 2kb

1173 from dbSNP Build 142
Strain Annotations

19
PCR

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345279	protein coding gene	Chr15:100285779-100322953 (-)
129S1/SvImJ	ENSMUSG00200051844	protein coding gene	Chr15:97491790-97527952 (-)
A/J	ENSMUSG00195036646	protein coding gene	Chr15:97369138-97405453 (-)
AKR/J	ENSMUSG00220043846	protein coding gene	Chr15:97362373-97398685 (-)
BALB/cJ	ENSMUSG00180035630	protein coding gene	Chr15:97267630-97303765 (-)
C3H/HeJ	ENSMUSG00175040417	protein coding gene	Chr15:97549119-97585439 (-)
C57BL/6NJ	ENSMUSG00215049752	protein coding gene	Chr15:97324209-97360523 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020289	protein coding gene	Chr15:94085834-94122828 (-)
CAST/EiJ	ENSTCUG00005041275	protein coding gene	Chr15:96801874-96838245 (-)
CBA/J	ENSMUSG00210028143	protein coding gene	Chr15:97324481-97360614 (-)
DBA/2J	ENSMUSG00185039268	protein coding gene	Chr15:97368723-97405039 (-)
FVB/NJ	ENSMUSG00205023116	protein coding gene	Chr15:97073231-97109547 (-)
JF1/MsJ	ENSUMUG00000051970	protein coding gene	Chr15:96825138-96861362 (-)
LP/J	ENSMUSG00230039331	protein coding gene	Chr15:100715128-100751287 (-)
NOD/ShiLtJ	ENSMUSG00190046640	protein coding gene	Chr15:97298127-97334298 (-)
NZO/HlLtJ	ENSMUSG00225041986	protein coding gene	Chr15:100915104-100951274 (-)
PWK/PhJ	ENSLUMG00010048856	protein coding gene	Chr15:97036398-97072734 (-)
SPRET/EiJ	ENSMSPG00010048246	protein coding gene	Chr15:98855997-98891076 (-)
WSB/EiJ	ENSIUOG00005034533	protein coding gene	Chr15:97455393-97491563 (-)

Human Ortholog

SLC11A2, solute carrier family 11 member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC11A2, solute carrier family 11 member 2
Synonyms

AHMIO1, DCT1, DMT1, NRAMP2
Links

HGNC:10908

NCBI Gene ID: 4891

UniProt: P49281
Chr Location

12q13.12; chr12:50952263-51028886 (-) GRCh38

MGI Vertebrate Homology

Slc11a2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC11A2
Gene Tree

Slc11a2

Diseases

4 with human SLC11A2 associations

				Human Disease	Mouse Models
				amyotrophic lateral sclerosis IDs amyotrophic lateral sclerosis DOID:332 ICD10CM:G12.21 ICD9CM:335.20 KEGG:05014 MESH:D000690 NCI:C34373 OMIM:PS105400 ORDO:803 UMLS_CUI:C0002736
				anemia IDs anemia DOID:2355 EFO:0004272 ICD10CM:D64.9 ICD9CM:285.9 MESH:D000740 NCI:C2869 UMLS_CUI:C0002871
				hypochromic anemia IDs hypochromic anemia DOID:11759 ICD10CM:D50 MESH:D000747 NCI:C34380 UMLS_CUI:C0002884
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

45 phenotypes from 3 alleles in 7 genetic backgrounds
6 phenotypes from multigenic genotypes
68 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

7
Radiation induced

2
Spontaneous

2
Targeted

4
Transgenic

3
Genomic Mutations

3 involving Slc11a2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a spontaneous mutation exhibit microcytic, hypochromic anemia associated with impaired intestinal iron absorption and erythroblast iron uptake. Mutants have reduced viability and fertility.

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All GO Annotations

173
GO References

31

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

632
Tissues

23
cDNA Data

14
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc11a2

ZFIN slc11a2

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All Sequences

94
RefSeq

22
UniProt

6
CCDS

CCDS37211.1, CCDS49733.1

Ensembl

ENSMUSG00000023030 (Evidence)
NCBI Gene

18174

			Length	Strain/Species	Flank
genomic	18174	NCBI Gene Model \| MGI Sequence Detail	36312	C57BL/6J	± kb
transcript	NM_001146161	RefSeq \| MGI Sequence Detail	4373	ZRU/MplStud
polypeptide	P49282	UniProt \| EBI \| MGI Sequence Detail	568	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000002993 natural resistance-associated macrophage protein 2

(term hierarchy)
InterPro Domains

IPR001046 NRAMP family
GlyGen

P49282 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 20

cDNA 14

Primer pair 5

Other 1

Antibodies 3

Microarray probesets 6

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MGD-MRK-12247, MGD-MRK-15380, MGD-MRK-24100, MGI:103229, MGI:96993

Summaries

All 144

Developmental Gene Expression 11

Diseases 1

Gene Ontology 31

Phenotypes 68
Earliest

J:5167 Russell ES, et al., Characterization and genetic studies of microcytic anemia in house mouse. Blood. 1970 Jun;35(6):838-50
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Slc11a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136428	Chr15:100322979-100322986 (-)	-893 bp
Tssr136427	Chr15:100322931-100322956 (-)	-854 bp
Tssr136426	Chr15:100322089-100322100 (-)	-5 bp
Tssr136425	Chr15:100322050-100322054 (-)	38 bp
Tssr136424	Chr15:100320926-100320937 (-)	1,158 bp
Tssr136423	Chr15:100320872-100320920 (-)	1,194 bp
Tssr136422	Chr15:100315986-100315992 (-)	6,101 bp
Tssr136421	Chr15:100313671-100313682 (-)	8,413 bp
Tssr136420	Chr15:100313625-100313640 (-)	8,457 bp
Tssr136419	Chr15:100308040-100308048 (-)	14,046 bp
Tssr136418	Chr15:100301318-100301337 (-)	20,762 bp
Tssr136417	Chr15:100301289-100301309 (-)	20,791 bp
Tssr136416	Chr15:100301263-100301281 (-)	20,818 bp
Tssr136415	Chr15:100301215-100301225 (-)	20,870 bp
Tssr136414	Chr15:100301139-100301151 (-)	20,945 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24