About   Help   FAQ
Lynx1 Gene Detail
Summary
  • Symbol
    Lynx1
  • Name
    Ly6/neurotoxin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345180
    NCBI Gene: 23936
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:74619705-74624828 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345180
 protein coding gene Chr15:74619701-74624895 (-)
129S1/SvImJ ENSMUSG00200052584
 protein coding gene Chr15:71723700-71728908 (-)
A/J ENSMUSG00195041756
 protein coding gene Chr15:71792722-71797916 (-)
AKR/J ENSMUSG00220048825
 protein coding gene Chr15:71713273-71718467 (-)
BALB/cJ ENSMUSG00180046094
 protein coding gene Chr15:71565187-71570381 (-)
C3H/HeJ ENSMUSG00175049296
 protein coding gene Chr15:71927120-71932314 (-)
C57BL/6NJ ENSMUSG00215049825
 protein coding gene Chr15:71622352-71627546 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019878
 protein coding gene Chr15:68283729-68288905 (-)
CAST/EiJ ENSTCUG00005045917
 protein coding gene Chr15:71224112-71229288 (-)
CBA/J ENSMUSG00210046447
 protein coding gene Chr15:71702477-71707671 (-)
DBA/2J ENSMUSG00185039306
 protein coding gene Chr15:71647865-71653059 (-)
FVB/NJ ENSMUSG00205032003
 protein coding gene Chr15:71393730-71398924 (-)
JF1/MsJ ENSUMUG00000032275
 protein coding gene Chr15:71286443-71291618 (-)
LP/J ENSMUSG00230050429
 protein coding gene Chr15:75011936-75017130 (-)
NOD/ShiLtJ ENSMUSG00190051441
 protein coding gene Chr15:71758743-71763937 (-)
NZO/HlLtJ ENSMUSG00225048553
 protein coding gene Chr15:75285488-75290683 (-)
PWK/PhJ ENSLUMG00010043509
 protein coding gene Chr15:71564493-71569698 (-)
SPRET/EiJ ENSMSPG00010046992
 protein coding gene Chr15:73248753-73253952 (-)
WSB/EiJ ENSIUOG00005042660
 protein coding gene Chr15:71744570-71749764 (-)



Homology
more
  • Human Ortholog
    LYNX1, Ly6/neurotoxin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYNX1, Ly6/neurotoxin 1
  • Links
    NCBI Gene ID: 66004
    UniProt: P0DP58

  • Chr Location
    8q24.3; chr8:142771197-142777872 (-)  GRCh38
  • Human Ortholog
    LYNX1-SLURP2, LYNX1-SLURP2 readthrough
  • Links
    NCBI Gene ID: 111188157

  • Chr Location
    chr8:142764334-142778224 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased sensitivity to nicotine, neurodegeneration, brain vacuoles amd improved cue-conditioned learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    132
  • cDNA Data
    29
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23936 NCBI Gene Model | MGI Sequence Detail 5124 C57BL/6J ±  kb
    transcript NM_011838 RefSeq | MGI Sequence Detail 3952 C57BL/6  
    polypeptide P0DP60 UniProt | EBI | MGI Sequence Detail 116 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 30
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146067
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 8
      Phenotypes 40
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory