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Kcnk7 Gene Detail
Summary
  • Symbol
    Kcnk7
  • Name
    potassium channel, subfamily K, member 7
  • Synonyms
    2310014G03Rik, Kcnk8, Knot, Mlk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341841
    NCBI Gene: 16530
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr19:5754395-5757137 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341841
 protein coding gene Chr19:5754395-5757956 (+)
129S1/SvImJ ENSMUSG00200044246
 protein coding gene Chr19:2516721-2519463 (+)
A/J ENSMUSG00195045079
 protein coding gene Chr19:2912152-2914894 (+)
AKR/J ENSMUSG00220039907
 protein coding gene Chr19:2685282-2688024 (+)
BALB/cJ ENSMUSG00180035523
 protein coding gene Chr19:3286862-3289604 (+)
C3H/HeJ ENSMUSG00175010890
 protein coding gene Chr19:2537069-2539811 (+)
C57BL/6NJ ENSMUSG00215043918
 protein coding gene Chr19:2754934-2757677 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022566
 protein coding gene Chr19:2452357-2455203 (+)
CAST/EiJ ENSTCUG00005036432
 protein coding gene Chr19:2674720-2677453 (+)
CBA/J ENSMUSG00210049267
 protein coding gene Chr19:2539987-2542727 (+)
DBA/2J ENSMUSG00185039478
 protein coding gene Chr19:2916470-2919210 (+)
FVB/NJ ENSMUSG00205050638
 protein coding gene Chr19:2922574-2925316 (+)
JF1/MsJ ENSUMUG00000041412
 protein coding gene Chr19:2892002-2894750 (+)
LP/J ENSMUSG00230052705
 protein coding gene Chr19:3823634-3826376 (+)
NOD/ShiLtJ ENSMUSG00190022358
 protein coding gene Chr19:2446672-2449414 (+)
NZO/HlLtJ ENSMUSG00225026707
 protein coding gene Chr19:7532397-7535139 (+)
PWK/PhJ ENSLUMG00010003857
 protein coding gene Chr19:2659789-2662535 (+)
SPRET/EiJ ENSMSPG00010048174
 protein coding gene Chr19:2649791-2652528 (+)
WSB/EiJ ENSIUOG00005050439
 protein coding gene Chr19:2554591-2557335 (+)



Homology
more
  • Human Ortholog
    KCNK7, potassium two pore domain channel subfamily K member 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNK7, potassium two pore domain channel subfamily K member 7
  • Synonyms
    K2p7.1, TWIK3
  • Links
    NCBI Gene ID: 10089
    UniProt: Q9Y2U2

  • Chr Location
    11q13.1; chr11:65592836-65595996 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and behaviorally normal with no significant alterations in volatile anesthetic sensitivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    632
  • Tissues
    26
  • cDNA Data
    5
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024936 Ensembl Gene Model | MGI Sequence Detail 2743 C57BL/6J ±  kb
transcript ENSMUST00000052448 Ensembl | MGI Sequence Detail 1226 Not Applicable  
polypeptide ENSMUSP00000051278 Ensembl | MGI Sequence Detail 343 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    Genomic 2
    cDNA 6
    Primer pair 1
    Antibodies 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1923699
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:54624 Salinas M, et al., Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. J Biol Chem. 1999 Apr 23;274(17):11751-60
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory