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Mlf1 Gene Detail
Summary
  • Symbol
    Mlf1
  • Name
    myeloid leukemia factor 1
  • Synonyms
    HLS7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341819
    NCBI Gene: 17349
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:67281430-67307333 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 30.91 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    605 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341819
 protein coding gene Chr3:67281430-67307336 (+)
129S1/SvImJ ENSMUSG00200001145
 protein coding gene Chr3:64036384-64062282 (+)
A/J ENSMUSG00195026053
 protein coding gene Chr3:64150533-64176454 (+)
AKR/J ENSMUSG00220023911
 protein coding gene Chr3:64188141-64214069 (+)
BALB/cJ ENSMUSG00180008097
 protein coding gene Chr3:64200470-64226403 (+)
C3H/HeJ ENSMUSG00175003301
 protein coding gene Chr3:64058240-64084145 (+)
C57BL/6NJ ENSMUSG00215005734
 protein coding gene Chr3:64496836-64522749 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025051
 protein coding gene Chr3:60913434-60939971 (+)
CAST/EiJ ENSTCUG00005022060
 protein coding gene Chr3:63696175-63722235 (+)
CBA/J ENSMUSG00210001723
 protein coding gene Chr3:64142844-64168769 (+)
DBA/2J ENSMUSG00185014708
 protein coding gene Chr3:64304635-64330564 (+)
FVB/NJ ENSMUSG00205008965
 protein coding gene Chr3:63216078-63242015 (+)
JF1/MsJ ENSUMUG00000000828
 protein coding gene Chr3:63917398-63943333 (+)
LP/J ENSMUSG00230002025
 protein coding gene Chr3:66319022-66344912 (+)
NOD/ShiLtJ ENSMUSG00190002949
 protein coding gene Chr3:64601162-64627095 (+)
NZO/HlLtJ ENSMUSG00225002016
 protein coding gene Chr3:69036839-69062744 (+)
PWK/PhJ ENSLUMG00010014641
 protein coding gene Chr3:63979107-64005006 (+)
SPRET/EiJ ENSMSPG00010007635
 protein coding gene Chr3:64466228-64492047 (+)
WSB/EiJ ENSIUOG00005015741
 protein coding gene Chr3:64521335-64547268 (+)



Homology
more
  • Human Ortholog
    MLF1, myeloid leukemia factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MLF1, myeloid leukemia factor 1
  • Links
    NCBI Gene ID: 4291
    UniProt: P58340

  • Chr Location
    3q25.32; chr3:158571163-158607252 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Mlf1
  • Find Mice (IMSR)
    21 strains or lines available
Mice homozygous for a null allele exhibit a slight increased B cells in the spleen and decreased ex vivo thymocyte apoptosis susceptibility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    667
  • Tissues
    29
  • cDNA Data
    70
  • Literature Summary
    14
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17349 NCBI Gene Model | MGI Sequence Detail 25904 C57BL/6J ±  kb
transcript NM_001039543 RefSeq | MGI Sequence Detail 1178 ZRU/MplStud  
polypeptide Q9QWV4 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 73
    cDNA 70
    Primer pair 2
    Other 1
    Antibodies 1

    Microarray probesets 3
References
more
  • Summaries
    All 53
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 11
    Phenotypes 11
  • Earliest
    J:56033 Hitzler JK, et al., cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia. Am J Pathol. 1999 Jul;155(1):53-9
  • Latest
    J:373442 Zhou Y, et al., Loss-of-function variants in ciliary genes confer high risk for tetralogy of Fallot. Sci Adv. 2025 Oct 10;11(41):eadt0836
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory