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Nfe2l3 Gene Detail
Summary
  • Symbol
    Nfe2l3
  • Name
    nuclear factor, erythroid derived 2, like 3
  • Synonyms
    Nrf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339958
    NCBI Gene: 18025
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:51409650-51435748 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 24.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    814 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339958
 protein coding gene Chr6:51409649-51435752 (+)
129S1/SvImJ ENSMUSG00200005160
 protein coding gene Chr6:48381944-48408033 (+)
A/J ENSMUSG00195006772
 protein coding gene Chr6:48107860-48133953 (+)
AKR/J ENSMUSG00220002911
 protein coding gene Chr6:47809152-47835155 (+)
BALB/cJ ENSMUSG00180020302
 protein coding gene Chr6:48409791-48435797 (+)
C3H/HeJ ENSMUSG00175015503
 protein coding gene Chr6:48176193-48202280 (+)
C57BL/6NJ ENSMUSG00215008626
 protein coding gene Chr6:48362376-48388482 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028376
 protein coding gene Chr6:45927687-45953205 (+)
CAST/EiJ ENSTCUG00005004877
 protein coding gene Chr6:47660764-47687320 (+)
CBA/J ENSMUSG00210018175
 protein coding gene Chr6:48220473-48246557 (+)
DBA/2J ENSMUSG00185012917
 protein coding gene Chr6:48802752-48828836 (+)
FVB/NJ ENSMUSG00205025000
 protein coding gene Chr6:48460878-48486961 (+)
JF1/MsJ ENSUMUG00000007980
 protein coding gene Chr6:48162516-48188969 (+)
LP/J ENSMUSG00230018108
 protein coding gene Chr6:49879257-49905341 (+)
NOD/ShiLtJ ENSMUSG00190029514
 protein coding gene Chr6:48140208-48166323 (+)
NZO/HlLtJ ENSMUSG00225012948
 protein coding gene Chr6:51860518-51886619 (+)
PWK/PhJ ENSLUMG00010019486
 protein coding gene Chr6:47886194-47912665 (+)
SPRET/EiJ ENSMSPG00010008109
 protein coding gene Chr6:48499676-48525971 (+)
WSB/EiJ ENSIUOG00005026978
 protein coding gene Chr6:48477768-48503967 (+)



Homology
more
  • Human Ortholog
    NFE2L3, NFE2 like bZIP transcription factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFE2L3, NFE2 like bZIP transcription factor 3
  • Synonyms
    NRF3
  • Links
    NCBI Gene ID: 9603
    UniProt: Q9Y4A8

  • Chr Location
    7p15.2; chr7:26152190-26187137 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    8 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    666
  • Tissues
    30
  • cDNA Data
    41
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029832 Ensembl Gene Model | MGI Sequence Detail 26099 C57BL/6J ±  kb
transcript ENSMUST00000005103 Ensembl | MGI Sequence Detail 2544 Not Applicable  
polypeptide ENSMUSP00000005103 Ensembl | MGI Sequence Detail 660 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000011171 nuclear factor erythroid 2-related factor 3
    (term hierarchy)
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR004826 Basic leucine zipper domain, Maf-type
    IPR046347 Basic-leucine zipper domain superfamily
    IPR047167 Nuclear Factor Erythroid-derived 2-like
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
  • GlyGen
    Q9WTM4 1 site
Molecular
Reagents
less
  • All nucleic 45
    cDNA 41
    Primer pair 2
    Other 2

    Microarray probesets 5
References
more
  • Summaries
    All 53
    Developmental Gene Expression 12
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:53336 Kobayashi A, et al., Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J Biol Chem. 1999 Mar 5;274(10):6443-52
  • Latest
    J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory