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Padi3 Gene Detail
Summary
  • Symbol
    Padi3
  • Name
    peptidyl arginine deiminase, type III
  • Synonyms
    Pad3, PAD type III, Pdi3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338891
    NCBI Gene: 18601
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:140512680-140537959 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 72.50 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    386 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338891
 protein coding gene Chr4:140512676-140537959 (-)
129S1/SvImJ ENSMUSG00200042162
 protein coding gene Chr4:133931948-133957558 (-)
A/J ENSMUSG00195030587
 protein coding gene Chr4:135278472-135303796 (-)
AKR/J ENSMUSG00220040161
 protein coding gene Chr4:134278461-134308997 (-)
BALB/cJ ENSMUSG00180043195
 protein coding gene Chr4:132918311-132948847 (-)
C3H/HeJ ENSMUSG00175033949
 protein coding gene Chr4:133946171-133971505 (-)
C57BL/6NJ ENSMUSG00215047848
 protein coding gene Chr4:135464023-135489353 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026725
 protein coding gene Chr4:130468451-130494191 (-)
CAST/EiJ ENSTCUG00005013269
 protein coding gene Chr4:134902965-134928417 (-)
CBA/J ENSMUSG00210027328
 protein coding gene Chr4:133570180-133595497 (-)
DBA/2J ENSMUSG00185049839
 protein coding gene Chr4:135080498-135111032 (-)
FVB/NJ ENSMUSG00205040587
 protein coding gene Chr4:133341060-133366554 (-)
JF1/MsJ ENSUMUG00000044370
 protein coding gene Chr4:135771839-135797203 (-)
LP/J ENSMUSG00230033184
 protein coding gene Chr4:138870511-138896166 (-)
NOD/ShiLtJ ENSMUSG00190021893
 protein coding gene Chr4:133335696-133361196 (-)
NZO/HlLtJ ENSMUSG00225008042
 protein coding gene Chr4:144827340-144853278 (-)
PWK/PhJ ENSLUMG00010040087
 protein coding gene Chr4:132766068-132796469 (-)
SPRET/EiJ ENSMSPG00010029748
 protein coding gene Chr4:134824200-134842968 (-)
WSB/EiJ ENSIUOG00005040699
 protein coding gene Chr4:133221524-133252016 (-)



Homology
more
  • Human Ortholog
    PADI3, peptidyl arginine deiminase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PADI3, peptidyl arginine deiminase 3
  • Synonyms
    PAD3, PDI3, UHS1
  • Links
    NCBI Gene ID: 51702
    UniProt: Q9ULW8

  • Chr Location
    1p36.13; chr1:17249098-17284233 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit alterations in coat/ hair and vibrissa morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    107
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18601 NCBI Gene Model | MGI Sequence Detail 25280 C57BL/6J ±  kb
    transcript NM_011060 RefSeq | MGI Sequence Detail 3068 Not Specified  
    polypeptide Q9Z184 UniProt | EBI | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140319
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:53035 Rus'd AA, et al., Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse. Eur J Biochem. 1999 Feb;259(3):660-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory