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Pex16 Gene Detail
Summary
  • Symbol
    Pex16
  • Name
    peroxisomal biogenesis factor 16
  • Synonyms
    peroxisome biogenesis factor 16
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338829
    NCBI Gene: 18633
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:92205043-92211563 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.98 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338829
 protein coding gene Chr2:92205021-92211563 (+)
129S1/SvImJ ENSMUSG00200052029
 protein coding gene Chr2:89118709-89130653 (+)
A/J ENSMUSG00195053065
 protein coding gene Chr2:89254196-89266132 (+)
AKR/J ENSMUSG00220049289
 protein coding gene Chr2:89048719-89060869 (+)
BALB/cJ ENSMUSG00180054611
 protein coding gene Chr2:89153426-89165370 (+)
C3H/HeJ ENSMUSG00175053736
 protein coding gene Chr2:89413397-89425547 (+)
C57BL/6NJ ENSMUSG00215052548
 protein coding gene Chr2:89245926-89257869 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023977
 protein coding gene Chr2:86500622-86507106 (+)
CAST/EiJ ENSTCUG00005051739
 protein coding gene Chr2:88659167-88671599 (+)
CBA/J ENSMUSG00210032737
 protein coding gene Chr2:89425932-89437876 (+)
DBA/2J ENSMUSG00185056078
 protein coding gene Chr2:89149806-89161750 (+)
FVB/NJ ENSMUSG00205051924
 protein coding gene Chr2:88435278-88447428 (+)
JF1/MsJ ENSUMUG00000028987
 protein coding gene Chr2:88969936-88982363 (+)
LP/J ENSMUSG00230039570
 protein coding gene Chr2:90900324-90912268 (+)
NOD/ShiLtJ ENSMUSG00190040374
 protein coding gene Chr2:89228451-89240395 (+)
NZO/HlLtJ ENSMUSG00225051218
 protein coding gene Chr2:98815539-98827483 (+)
PWK/PhJ ENSLUMG00010050411
 protein coding gene Chr2:88946706-88959132 (+)
SPRET/EiJ ENSMSPG00010052036
 protein coding gene Chr2:90910277-90917843 (+)
WSB/EiJ ENSIUOG00005053318
 protein coding gene Chr2:88954517-88966453 (+)



Homology
more
  • Human Ortholog
    PEX16, peroxisomal biogenesis factor 16
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEX16, peroxisomal biogenesis factor 16
  • Synonyms
    PBD8A, PBD8B
  • Links
    NCBI Gene ID: 9409
    UniProt: Q9Y5Y5

  • Chr Location
    11p11.2; chr11:45909663-45918822 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PEX16 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in adipose tissue exhibit impaired cold tolerance, decreased energy expenditure, and increased diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    3
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18633 NCBI Gene Model | MGI Sequence Detail 6521 C57BL/6J ±  kb
    transcript NM_001420534 RefSeq | MGI Sequence Detail 1261 C57BL/6  
    polypeptide Q91XC9 UniProt | EBI | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:373760 Chen X, et al., PPARalpha regulates acyl-CoA oxidase 1 (ACOX1) but not catalase. Biochem Biophys Res Commun. 2025 Sep 1;777:152247
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory