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Rbm6 Gene Detail
Summary
  • Symbol
    Rbm6
  • Name
    RNA binding motif protein 6
  • Synonyms
    Def-3, g16, NY-LU-12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338037
    NCBI Gene: 19654
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107650758-107750436 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.07 cM, cytoband F1-F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2244 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338037
 protein coding gene Chr9:107650758-107751028 (-)
129S1/SvImJ ENSMUSG00200043443
 protein coding gene Chr9:104928408-104935598 (-)
129S1/SvImJ ENSMUSGG00200054509
 protein coding gene Chr9:104848084-104928811 (-)
A/J ENSMUSGG00195055405
 protein coding gene Chr9:104066818-104147554 (-)
A/J ENSMUSG00195037487
 protein coding gene Chr9:104147151-104154346 (-)
AKR/J ENSMUSG00220024371
 protein coding gene Chr9:104534137-104541304 (-)
AKR/J ENSMUSGG00220054413
 protein coding gene Chr9:104457033-104534540 (-)
BALB/cJ ENSMUSG00180033225
 protein coding gene Chr9:104463666-104470855 (-)
BALB/cJ ENSMUSGG00180055108
 protein coding gene Chr9:104383288-104464069 (-)
C3H/HeJ ENSMUSG00175043618
 protein coding gene Chr9:104805963-104813153 (-)
C3H/HeJ ENSMUSGG00175055123
 protein coding gene Chr9:104725587-104806366 (-)
C57BL/6NJ ENSMUSG00215030383
 protein coding gene Chr9:104783063-104790250 (-)
C57BL/6NJ ENSMUSGG00215055253
 protein coding gene Chr9:104703337-104783466 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032661
 protein coding gene Chr9:103103549-103203583 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054672
 protein coding gene Chr9:104574551-104654670 (-)
CBA/J ENSMUSG00210035798
 protein coding gene Chr9:104654267-104661417 (-)
DBA/2J ENSMUSG00185037308
 protein coding gene Chr9:104814933-104822104 (-)
DBA/2J ENSMUSGG00185057418
 protein coding gene Chr9:104737825-104815336 (-)
FVB/NJ ENSMUSG00205047922
 protein coding gene Chr9:104816694-104823884 (-)
FVB/NJ ENSMUSGG00205054117
 protein coding gene Chr9:104736295-104817097 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055799
 protein coding gene Chr9:104877001-104957723 (-)
LP/J ENSMUSG00230050093
 protein coding gene Chr9:104957320-104964504 (-)
NOD/ShiLtJ ENSMUSGG00190055042
 protein coding gene Chr9:104373481-104454253 (-)
NOD/ShiLtJ ENSMUSG00190048475
 protein coding gene Chr9:104453850-104461041 (-)
NZO/HlLtJ ENSMUSGG00225055214
 protein coding gene Chr9:105111128-105188640 (-)
NZO/HlLtJ ENSMUSG00225023944
 protein coding gene Chr9:105188237-105195408 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010040972
 protein coding gene Chr9:106350661-106450574 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RBM6, RNA binding motif protein 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBM6, RNA binding motif protein 6
  • Synonyms
    3G2, DEF-3, DEF3, g16, HLC-11, NY-LU-12
  • Links
    NCBI Gene ID: 10180
    UniProt: P78332

  • Chr Location
    3p21.31; chr3:49940007-50100045 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    34
  • cDNA Data
    109
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032582 Ensembl Gene Model | MGI Sequence Detail 99679 C57BL/6J ±  kb
transcript ENSMUST00000183032 Ensembl | MGI Sequence Detail 3716 Not Applicable  
polypeptide ENSMUSP00000138400 Ensembl | MGI Sequence Detail 1118 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 115
    Genomic 1
    cDNA 112
    Primer pair 1
    Other 1

    Microarray probesets 6
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:54520 Drabkin HA, et al., DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC. Oncogene. 1999 Apr 22;18(16):2589-97
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory