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Galr2 Gene Detail
Summary
  • Symbol
    Galr2
  • Name
    galanin receptor 2
  • Synonyms
    GalR2, mGalR
Location &
Maps
more
  • Sequence Map
    Chr11:116171765-116174764 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.10 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337018
 protein coding gene Chr11:116170520-116174776 (+)
129S1/SvImJ ENSMUSG00200047349
 protein coding gene Chr11:113538658-113541657 (+)
A/J ENSMUSG00195028082
 protein coding gene Chr11:113243122-113246121 (+)
AKR/J ENSMUSG00220029509
 protein coding gene Chr11:113347283-113350281 (+)
BALB/cJ ENSMUSG00180048584
 protein coding gene Chr11:113539772-113542770 (+)
C3H/HeJ ENSMUSG00175037273
 protein coding gene Chr11:113494889-113497887 (+)
C57BL/6NJ ENSMUSG00215043707
 protein coding gene Chr11:113031928-113034927 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017438
 protein coding gene Chr11:112133360-112136348 (+)
CAST/EiJ ENSTCUG00005032775
 protein coding gene Chr11:112897386-112900370 (+)
CBA/J ENSMUSG00210050564
 protein coding gene Chr11:113214881-113217879 (+)
DBA/2J ENSMUSG00185025462
 protein coding gene Chr11:113531270-113534268 (+)
FVB/NJ ENSMUSG00205043601
 protein coding gene Chr11:113336613-113339610 (+)
JF1/MsJ ENSUMUG00000052419
 protein coding gene Chr11:113798883-113801865 (+)
LP/J ENSMUSG00230050683
 protein coding gene Chr11:114588213-114591211 (+)
NOD/ShiLtJ ENSMUSG00190028078
 protein coding gene Chr11:113562470-113565469 (+)
NZO/HlLtJ ENSMUSG00225049375
 protein coding gene Chr11:116640614-116643613 (+)
PWK/PhJ ENSLUMG00010019024
 protein coding gene Chr11:113315181-113318160 (+)
SPRET/EiJ ENSMSPG00010034952
 protein coding gene Chr11:113835296-113838287 (+)
WSB/EiJ ENSIUOG00005037495
 protein coding gene Chr11:113302851-113305848 (+)



Homology
more
  • Human Ortholog
    GALR2, galanin receptor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GALR2, galanin receptor 2
  • Synonyms
    GAL2-R, GALNR2, GALR-2
  • Links
    NCBI Gene ID: 8811
    UniProt: O43603

  • Chr Location
    17q25.1; chr17:76071962-76077537 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a reduction in exploratory activity. There is also a modest shift in the distribution of different lymphocyte cell types.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    5
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020793 Ensembl Gene Model | MGI Sequence Detail 3000 C57BL/6J ±  kb
    transcript ENSMUST00000055872 Ensembl | MGI Sequence Detail 1940 Not Applicable  
    polypeptide ENSMUSP00000054062 Ensembl | MGI Sequence Detail 371 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 29
    • Earliest
      J:51042 Pang L, et al., The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization. J Neurochem. 1998 Dec;71(6):2252-9
    • Latest
      J:372809 Brunner SM, et al., Impact of galanin receptors 2 and 3 double-knockout on neuroinflammation and functional recovery following traumatic brain injury. Peptides. 2025 Sep;191:171415
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory