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Vbp1 Gene Detail
Summary
  • Symbol
    Vbp1
  • Name
    von Hippel-Lindau binding protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333804
    NCBI Gene: 22327
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74557905-74578548 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.25 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333804
 protein coding gene ChrX:74557903-74578552 (+)
129S1/SvImJ ENSMUSG00200040764
 protein coding gene ChrX:56573129-56593770 (+)
A/J ENSMUSG00195031277
 protein coding gene ChrX:60298794-60319443 (+)
AKR/J ENSMUSG00220045531
 protein coding gene ChrX:55453151-55473796 (+)
BALB/cJ ENSMUSG00180049342
 protein coding gene ChrX:56873518-56894167 (+)
C3H/HeJ ENSMUSG00175034409
 protein coding gene ChrX:60464010-60484653 (+)
C57BL/6NJ ENSMUSG00215038230
 protein coding gene ChrX:56959507-56980152 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005039471
 protein coding gene ChrX:58339978-58360710 (+)
CBA/J ENSMUSG00210042878
 protein coding gene ChrX:57143810-57164457 (+)
DBA/2J ENSMUSG00185032041
 protein coding gene ChrX:69565550-69586199 (+)
FVB/NJ ENSMUSG00205021952
 protein coding gene ChrX:56431258-56451896 (+)
JF1/MsJ ENSUMUG00000043158
 protein coding gene ChrX:90397082-90418001 (+)
LP/J ENSMUSG00230035691
 protein coding gene ChrX:76131698-76152336 (+)
NOD/ShiLtJ ENSMUSG00190038929
 protein coding gene ChrX:56383612-56404250 (+)
NZO/HlLtJ ENSMUSG00225047635
 protein coding gene ChrX:81348855-81369502 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010028564
 protein coding gene ChrX:59448770-59469470 (+)
WSB/EiJ ENSIUOG00005045150
 protein coding gene ChrX:57142338-57163005 (+)



Homology
more
  • Human Ortholog
    VBP1, VHL binding protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VBP1, VHL binding protein 1
  • Synonyms
    HIBBJ46, PFD3, PFDN3, VBP-1
  • Links
    NCBI Gene ID: 7411
    UniProt: P61758

  • Chr Location
    Xq28; chrX:155197007-155239841 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 images
    5 phenotype references
Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    662
  • Tissues
    49
  • cDNA Data
    119
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031197 Ensembl Gene Model | MGI Sequence Detail 20644 C57BL/6J ±  kb
transcript ENSMUST00000033540 Ensembl | MGI Sequence Detail 1595 Not Applicable  
polypeptide ENSMUSP00000033540 Ensembl | MGI Sequence Detail 196 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 121
    cDNA 119
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:43928 Brinke A, et al., Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue. Genomics. 1997 Oct 1;45(1):105-12
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory