About   Help   FAQ
Inppl1 Gene Detail
Summary
  • Symbol
    Inppl1
  • Name
    inositol polyphosphate phosphatase-like 1
  • Synonyms
    SHIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333787
    NCBI Gene: 16332
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101471839-101487419 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.67 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    372 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333787
 protein coding gene Chr7:101471839-101487436 (-)
129S1/SvImJ ENSMUSG00200044520
 protein coding gene Chr7:88313705-88329326 (-)
A/J ENSMUSG00195054414
 protein coding gene Chr7:92819353-92834974 (-)
AKR/J ENSMUSG00220047396
 protein coding gene Chr7:86235978-86251599 (-)
BALB/cJ ENSMUSG00180030636
 protein coding gene Chr7:89492291-89507911 (-)
C3H/HeJ ENSMUSG00175021073
 protein coding gene Chr7:90145888-90161487 (-)
C57BL/6NJ ENSMUSG00215023620
 protein coding gene Chr7:89318791-89334389 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030066
 protein coding gene Chr7:104520644-104536055 (-)
CAST/EiJ ENSTCUG00005052947
 protein coding gene Chr7:92727099-92743062 (-)
CBA/J ENSMUSG00210024814
 protein coding gene Chr7:89999321-90014918 (-)
DBA/2J ENSMUSG00185056113
 protein coding gene Chr7:94321063-94336659 (-)
FVB/NJ ENSMUSG00205035208
 protein coding gene Chr7:89990462-90006083 (-)
JF1/MsJ ENSUMUG00000040798
 protein coding gene Chr7:99222011-99237608 (-)
LP/J ENSMUSG00230041827
 protein coding gene Chr7:100427799-100443423 (-)
NOD/ShiLtJ ENSMUSG00190018625
 protein coding gene Chr7:90263122-90278753 (-)
NZO/HlLtJ ENSMUSG00225049363
 protein coding gene Chr7:98660220-98675844 (-)
PWK/PhJ ENSLUMG00010039922
 protein coding gene Chr7:88471631-88487221 (-)
SPRET/EiJ ENSMSPG00010010938
 protein coding gene Chr7:89714666-89729200 (-)
WSB/EiJ ENSIUOG00005008358
 protein coding gene Chr7:90584727-90600411 (-)



Homology
more
  • Human Ortholog
    INPPL1, inositol polyphosphate phosphatase like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INPPL1, inositol polyphosphate phosphatase like 1
  • Synonyms
    OPSMD, SHIP2
  • Links
    NCBI Gene ID: 3636
    UniProt: O15357

  • Chr Location
    11q13.4; chr11:72223524-72239184 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human INPPL1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice display decreased postnatal growth, decreased circulating levels of leptin, free fatty acids, triglycerides, and total cholesterol, and resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    126
  • cDNA Data
    82
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16332 NCBI Gene Model | MGI Sequence Detail 15581 C57BL/6J ±  kb
    transcript NM_001412588 RefSeq | MGI Sequence Detail 5316 C57BL/6  
    polypeptide Q6P549 UniProt | EBI | MGI Sequence Detail 1257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009053 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
      (term hierarchy)
    • PDB
      5ZRX
    • EC
      3.1.3.86
    • InterPro Domains
      IPR036691 Endonuclease/exonuclease/phosphatase superfamily
      IPR000300 Inositol polyphosphate-related phosphatase
      IPR057510 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, first C2 domain
      IPR057509 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, second C2 domain
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
    • GlyGen
      Q6P549 1 site
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 82
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 8
      Gene Ontology 17
      Phenotypes 23
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:336310 Fernandes S, et al., Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment. iScience. 2023 Feb 17;26(2):106071
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory