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Hdac5 Gene Detail
Summary
  • Symbol
    Hdac5
  • Name
    histone deacetylase 5
  • Synonyms
    mHDA1, mKIAA0600
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333784
    NCBI Gene: 15184
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102085244-102120968 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 65.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    725 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333784
 protein coding gene Chr11:102085244-102120992 (-)
129S1/SvImJ ENSMUSG00200052020
 protein coding gene Chr11:99371961-99402470 (-)
A/J ENSMUSG00195051990
 protein coding gene Chr11:99067630-99098140 (-)
AKR/J ENSMUSG00220050989
 protein coding gene Chr11:99287395-99317913 (-)
BALB/cJ ENSMUSG00180048692
 protein coding gene Chr11:99419591-99450100 (-)
C3H/HeJ ENSMUSG00175041544
 protein coding gene Chr11:99345461-99375974 (-)
C57BL/6NJ ENSMUSG00215053326
 protein coding gene Chr11:98906955-98937481 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017243
 protein coding gene Chr11:98138095-98174524 (-)
CAST/EiJ ENSTCUG00005050169
 protein coding gene Chr11:98841051-98871687 (-)
CBA/J ENSMUSG00210052957
 protein coding gene Chr11:99052802-99083331 (-)
DBA/2J ENSMUSG00185048138
 protein coding gene Chr11:99395323-99425830 (-)
FVB/NJ ENSMUSG00205048507
 protein coding gene Chr11:99237676-99268201 (-)
JF1/MsJ ENSUMUG00000051069
 protein coding gene Chr11:99655601-99686199 (-)
LP/J ENSMUSG00230050670
 protein coding gene Chr11:100447891-100478399 (-)
NOD/ShiLtJ ENSMUSG00190031987
 protein coding gene Chr11:99434010-99464494 (-)
NZO/HlLtJ ENSMUSG00225050487
 protein coding gene Chr11:102470644-102501133 (-)
PWK/PhJ ENSLUMG00010045177
 protein coding gene Chr11:99188710-99219271 (-)
SPRET/EiJ ENSMSPG00010044207
 protein coding gene Chr11:99686943-99717902 (-)
WSB/EiJ ENSIUOG00005049441
 protein coding gene Chr11:99188358-99218852 (-)



Homology
more
  • Human Ortholog
    HDAC5, histone deacetylase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDAC5, histone deacetylase 5
  • Synonyms
    HD5, NY-CO-9
  • Links
    NCBI Gene ID: 10014
    UniProt: Q9UQL6

  • Chr Location
    17q21.31; chr17:44076746-44123702 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and display cardiac hypertrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    97
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    67
  • cDNA Data
    139
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15184 NCBI Gene Model | MGI Sequence Detail 35725 C57BL/6J ±  kb
    transcript NM_001284248 RefSeq | MGI Sequence Detail 5613 C57BL/6  
    polypeptide Q9Z2V6 UniProt | EBI | MGI Sequence Detail 1113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 143
      cDNA 139
      Primer pair 4
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144155
    References
    more
    • Summaries
      All 250
      Developmental Gene Expression 27
      Gene Ontology 33
      Phenotypes 39
    • Earliest
      J:52197 Verdel A, et al., Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999 Jan 22;274(4):2440-5
    • Latest
      J:390468 Yang C, et al., Divergent Spatiotemporal Expression Patterns of Histone Deacetylases During Mouse Embryonic Tongue, Palate, and Mandible Development. Genesis. 2026 Aug;64(4):e70065
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory