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Trpt1 Gene Detail
Summary
  • Symbol
    Trpt1
  • Name
    tRNA phosphotransferase 1
  • Synonyms
    EST-MNCb3719, MGC:41710, TPT1, Tpt1h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333115
    NCBI Gene: 107328
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6973499-6976414 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333115
 protein coding gene Chr19:6970046-6977689 (+)
129S1/SvImJ ENSMUSG00200051370
 protein coding gene Chr19:3695557-3703290 (+)
A/J ENSMUSG00195049461
 protein coding gene Chr19:4097475-4105210 (+)
AKR/J ENSMUSG00220037276
 protein coding gene Chr19:3866906-3874641 (+)
BALB/cJ ENSMUSG00180045558
 protein coding gene Chr19:4461046-4468779 (+)
C3H/HeJ ENSMUSG00175011569
 protein coding gene Chr19:3717488-3725222 (+)
C57BL/6NJ ENSMUSG00215043634
 protein coding gene Chr19:3935987-3943720 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022627
 protein coding gene Chr19:3665776-3668624 (+)
CAST/EiJ ENSTCUG00005033845
 protein coding gene Chr19:3838837-3846567 (+)
CBA/J ENSMUSG00210049898
 protein coding gene Chr19:3720873-3728628 (+)
DBA/2J ENSMUSG00185048250
 protein coding gene Chr19:4097350-4105106 (+)
FVB/NJ ENSMUSG00205042268
 protein coding gene Chr19:4096402-4104158 (+)
JF1/MsJ ENSUMUG00000042381
 protein coding gene Chr19:4057102-4065260 (+)
LP/J ENSMUSG00230053683
 protein coding gene Chr19:5022294-5030027 (+)
NOD/ShiLtJ ENSMUSG00190046109
 protein coding gene Chr19:3628758-3636492 (+)
NZO/HlLtJ ENSMUSG00225026729
 protein coding gene Chr19:8731111-8738844 (+)
PWK/PhJ ENSLUMG00010006263
 protein coding gene Chr19:3821813-3829556 (+)
SPRET/EiJ ENSMSPG00010033924
 protein coding gene Chr19:3817384-3820256 (+)
WSB/EiJ ENSIUOG00005043076
 protein coding gene Chr19:3735056-3742809 (+)



Homology
more
  • Human Ortholog
    TRPT1, tRNA phosphotransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPT1, tRNA phosphotransferase 1
  • Links
    NCBI Gene ID: 83707
    UniProt: Q86TN4

  • Chr Location
    11q13.1; chr11:64223799-64226823 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    6 phenotype references
Mice homozygous for a knock-out allele exhibit normal glucose tolerance and translation of tyrosine-rich proteins.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    12
  • cDNA Data
    6
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047656 Ensembl Gene Model | MGI Sequence Detail 2916 C57BL/6J ±  kb
transcript ENSMUST00000088223 Ensembl | MGI Sequence Detail 1103 Not Applicable  
polypeptide ENSMUSP00000085555 Ensembl | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2147684, MGI:2183030
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 6
  • Earliest
    J:51223 Spinelli SL, et al., A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14136-41
  • Latest
    J:383088 Yang X, et al., Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation. Nucleic Acids Res. 2023 Aug 11;51(14):7649-7665
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory