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Cds2 Gene Detail
Summary
  • Symbol
    Cds2
  • Name
    CDP-diacylglycerol synthase 2
  • Synonyms
    5730450N06Rik, 5730460C18Rik, D2Wsu127e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332236
    NCBI Gene: 110911
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:132105068-132153970 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 64.15 cM, cytoband G1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1566 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1332236
 protein coding gene Chr2:132105068-132153970 (+)
129S1/SvImJ ENSMUSG00200044391
 protein coding gene Chr2:129136178-129184948 (+)
A/J ENSMUSG00195027378
 protein coding gene Chr2:129181493-129230400 (+)
AKR/J ENSMUSG00220044202
 protein coding gene Chr2:128932475-128981063 (+)
BALB/cJ ENSMUSG00180043469
 protein coding gene Chr2:129000018-129048923 (+)
C3H/HeJ ENSMUSG00175039124
 protein coding gene Chr2:129522705-129571285 (+)
C57BL/6NJ ENSMUSG00215019290
 protein coding gene Chr2:129029444-129078347 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024339
 protein coding gene Chr2:125026473-125076657 (+)
CAST/EiJ ENSTCUG00005038778
 protein coding gene Chr2:128304640-128347367 (+)
CBA/J ENSMUSG00210029569
 protein coding gene Chr2:129379219-129427802 (+)
DBA/2J ENSMUSG00185033449
 protein coding gene Chr2:129041357-129090260 (+)
FVB/NJ ENSMUSG00205028080
 protein coding gene Chr2:128205768-128254676 (+)
JF1/MsJ ENSUMUG00000008174
 protein coding gene Chr2:128848899-128897460 (+)
LP/J ENSMUSG00230038239
 protein coding gene Chr2:130771244-130820021 (+)
NOD/ShiLtJ ENSMUSG00190012546
 protein coding gene Chr2:129121013-129169754 (+)
NZO/HlLtJ ENSMUSG00225026657
 protein coding gene Chr2:138682634-138731212 (+)
PWK/PhJ ENSLUMG00010039270
 protein coding gene Chr2:128836674-128886638 (+)
SPRET/EiJ ENSMSPG00010025186
 protein coding gene Chr2:131209243-131258245 (+)
WSB/EiJ ENSIUOG00005040603
 protein coding gene Chr2:128963318-129012232 (+)



Homology
more
  • Human Ortholog
    CDS2, CDP-diacylglycerol synthase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDS2, CDP-diacylglycerol synthase 2
  • Links
    NCBI Gene ID: 8760
    UniProt: O95674

  • Chr Location
    20p12.3; chr20:5126879-5197887 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a lethal phenotype. Heterozygotes show a distorted lymphocyte distribution and enhanced sensorimotor gating.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    169
  • cDNA Data
    159
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110911 NCBI Gene Model | MGI Sequence Detail 48903 C57BL/6J ±  kb
    transcript NM_138651 RefSeq | MGI Sequence Detail 8412 ZRU/MplStud  
    polypeptide Q99L43 UniProt | EBI | MGI Sequence Detail 444 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000005291 phosphatidate cytidylyltransferase 2
      (term hierarchy)
    • EC
      2.7.7.41
    • InterPro Domains
      IPR016720 Phosphatidate cytidylyltransferase, eukaryota
      IPR000374 Phosphatidate cytidylyltransferase site
    • GlyGen
      Q99L43 3 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 161
      cDNA 159
      Primer pair 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-35819, MGI:107353, MGI:1917815, MGI:1924099, MGI:2139105
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:358515 Collins DM, et al., CDS2 expression regulates de novo phosphatidic acid synthesis. Biochem J. 2024 Oct 16;481(20):1449-1473
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory