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Dmrt2 Gene Detail
Summary
  • Symbol
    Dmrt2
  • Name
    doublesex and mab-3 related transcription factor 2
  • Synonyms
    Terra
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330307
    NCBI Gene: 226049
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:25649775-25656355 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 20.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    283 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330307
 protein coding gene Chr19:25649758-25656355 (+)
129S1/SvImJ ENSMUSG00200019873
 protein coding gene Chr19:22381562-22388060 (+)
A/J ENSMUSG00195032787
 protein coding gene Chr19:22523617-22530176 (+)
AKR/J ENSMUSG00220019050
 protein coding gene Chr19:22563040-22569601 (+)
BALB/cJ ENSMUSG00180013398
 protein coding gene Chr19:22863147-22869705 (+)
C3H/HeJ ENSMUSG00175025245
 protein coding gene Chr19:22235970-22242480 (+)
C57BL/6NJ ENSMUSG00215015106
 protein coding gene Chr19:22261661-22268242 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022840
 protein coding gene Chr19:22807209-22813700 (+)
CAST/EiJ ENSTCUG00005017602
 protein coding gene Chr19:22124381-22130886 (+)
CBA/J ENSMUSG00210014308
 protein coding gene Chr19:22466968-22473478 (+)
DBA/2J ENSMUSG00185025931
 protein coding gene Chr19:22853593-22860103 (+)
FVB/NJ ENSMUSG00205009907
 protein coding gene Chr19:22281403-22287960 (+)
JF1/MsJ ENSUMUG00000018517
 protein coding gene Chr19:23065333-23071830 (+)
LP/J ENSMUSG00230025279
 protein coding gene Chr19:23691048-23697546 (+)
NOD/ShiLtJ ENSMUSG00190018827
 protein coding gene Chr19:22234239-22240780 (+)
NZO/HlLtJ ENSMUSG00225034239
 protein coding gene Chr19:27441894-27448392 (+)
PWK/PhJ ENSLUMG00010032205
 protein coding gene Chr19:22407517-22414039 (+)
SPRET/EiJ ENSMSPG00010035137
 protein coding gene Chr19:22420388-22426857 (+)
WSB/EiJ ENSIUOG00005027856
 protein coding gene Chr19:21946159-21952689 (+)



Homology
more
  • Human Ortholog
    DMRT2, doublesex and mab-3 related transcription factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMRT2, doublesex and mab-3 related transcription factor 2
  • Synonyms
    DSXL-2, SCDO7
  • Links
    NCBI Gene ID: 10655
    UniProt: Q9Y5R5

  • Chr Location
    9p24.3; chr9:1049000-1057563 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display perinatal lethality due to breathing difficulties, multiple axial skeletal defects including kinked tails and rib and vertebral malformations, and abnormal somite organization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1012
  • Tissues
    172
  • cDNA Data
    22
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048138 Ensembl Gene Model | MGI Sequence Detail 6581 C57BL/6J ±  kb
    transcript ENSMUST00000053068 Ensembl | MGI Sequence Detail 2337 Not Applicable  
    polypeptide ENSMUSP00000059654 Ensembl | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 23
      Primer pair 11
      Other 3
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 27
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:52603 Meng A, et al., A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development. 1999 Mar;126(6):1259-68
    • Latest
      J:364871 Casado-Navarro R, et al., Expression atlas of Dmrt genes across sex and development in the mouse brain: functional insights from the olfactory system. Biol Sex Differ. 2026;17(1):44
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory