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Nts Gene Detail
Summary
  • Symbol
    Nts
  • Name
    neurotensin
  • Synonyms
    5033428E16Rik, neuromedin N, NMN-125, NT/N, NTS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328351
    NCBI Gene: 67405
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:102317617-102326294 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 53.56 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    338 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328351
 protein coding gene Chr10:102317617-102326347 (-)
129S1/SvImJ ENSMUSG00200019346
 protein coding gene Chr10:98803868-98812630 (-)
A/J ENSMUSG00195015359
 protein coding gene Chr10:99235460-99244225 (-)
AKR/J ENSMUSG00220024594
 protein coding gene Chr10:98809912-98818661 (-)
BALB/cJ ENSMUSG00180009322
 protein coding gene Chr10:99242702-99251465 (-)
C3H/HeJ ENSMUSG00175005713
 protein coding gene Chr10:99124066-99132826 (-)
C57BL/6NJ ENSMUSG00215006211
 protein coding gene Chr10:98836821-98845578 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015774
 protein coding gene Chr10:95908679-95917271 (-)
CAST/EiJ ENSTCUG00005005493
 protein coding gene Chr10:98404071-98412834 (-)
CBA/J ENSMUSG00210022758
 protein coding gene Chr10:99014999-99023759 (-)
DBA/2J ENSMUSG00185018718
 protein coding gene Chr10:99184909-99193669 (-)
FVB/NJ ENSMUSG00205003169
 protein coding gene Chr10:98671685-98680438 (-)
JF1/MsJ ENSUMUG00000018369
 protein coding gene Chr10:100601698-100610436 (-)
LP/J ENSMUSG00230012271
 protein coding gene Chr10:101103122-101111884 (-)
NOD/ShiLtJ ENSMUSG00190024454
 protein coding gene Chr10:99296275-99305023 (-)
NZO/HlLtJ ENSMUSG00225040224
 protein coding gene Chr10:105334320-105343080 (-)
PWK/PhJ ENSLUMG00010005454
 protein coding gene Chr10:98866774-98875465 (-)
SPRET/EiJ ENSMSPG00010009046
 protein coding gene Chr10:100643666-100652933 (-)
WSB/EiJ ENSIUOG00005012832
 protein coding gene Chr10:98939016-98947773 (-)



Homology
more
  • Human Ortholog
    NTS, neurotensin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTS, neurotensin
  • Synonyms
    NMN-125, NN, NT, NT/N, NTS1
  • Links
    NCBI Gene ID: 4922
    UniProt: P30990

  • Chr Location
    12q21.31; chr12:85874162-85882992 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NTS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable, fertile, and grossly normal, but display altered responses to antipsychotic drugs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    135
  • cDNA Data
    19
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67405 NCBI Gene Model | MGI Sequence Detail 8678 C57BL/6J ±  kb
    transcript NM_001429471 RefSeq | MGI Sequence Detail 1267 C57BL/6  
    polypeptide Q9D3P9 UniProt | EBI | MGI Sequence Detail 169 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914655
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 31
      Gene Ontology 7
      Phenotypes 81
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:385796 Gingrich EC, et al., Ten3-Lphn2-mediated target selection across the extended hippocampal network demonstrates a repeated strategy for circuit assembly. Curr Biol. 2026 May 8;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory