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Hk2 Gene Detail
Summary
  • Symbol
    Hk2
  • Name
    hexokinase 2
  • Synonyms
    HKII
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315197
    NCBI Gene: 15277
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:82702006-82751435 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    668 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315197
 protein coding gene Chr6:82702004-82751437 (-)
129S1/SvImJ ENSMUSG00200010292
 protein coding gene Chr6:79663547-79713221 (-)
A/J ENSMUSG00195012006
 protein coding gene Chr6:79347981-79397609 (-)
AKR/J ENSMUSG00220001735
 protein coding gene Chr6:78292189-78340944 (-)
BALB/cJ ENSMUSG00180009677
 protein coding gene Chr6:79724076-79773703 (-)
C3H/HeJ ENSMUSG00175030105
 protein coding gene Chr6:97636716-97686149 (+)
C57BL/6NJ ENSMUSG00215011419
 protein coding gene Chr6:79721324-79770761 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028531
 protein coding gene Chr6:78864989-78913663 (-)
CAST/EiJ ENSTCUG00005007878
 protein coding gene Chr6:79727484-79776430 (-)
CBA/J ENSMUSG00210010816
 protein coding gene Chr6:79539760-79589194 (-)
DBA/2J ENSMUSG00185000855
 protein coding gene Chr6:80086771-80136209 (-)
FVB/NJ ENSMUSG00205015770
 protein coding gene Chr6:78765780-78815388 (-)
JF1/MsJ ENSUMUG00000009041
 protein coding gene Chr6:79133368-79182120 (-)
LP/J ENSMUSG00230044228
 protein coding gene Chr6:81220886-81270548 (-)
NOD/ShiLtJ ENSMUSG00190001217
 protein coding gene Chr6:79168983-79218601 (-)
NZO/HlLtJ ENSMUSG00225015747
 protein coding gene Chr6:83129856-83179056 (-)
PWK/PhJ ENSLUMG00010005821
 protein coding gene Chr6:78492217-78541010 (-)
SPRET/EiJ ENSMSPG00010029893
 protein coding gene Chr6:80644655-80693095 (-)
WSB/EiJ ENSIUOG00005017132
 protein coding gene Chr6:80107218-80156156 (-)



Homology
more
  • Human Ortholog
    HK2, hexokinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HK2, hexokinase 2
  • Synonyms
    HKII, HXK2
  • Links
    NCBI Gene ID: 3099
    UniProt: P52789

  • Chr Location
    2p12; chr2:74834079-74893359 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HK2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    1 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out mutation are severely growth retarded and die around E8.5. Interestingly, heterozygous mutant mice are viable and fertile, develop normally and do not exhibit impaired insulin action or glucose tolerance even when challenged with a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    837
  • Tissues
    143
  • cDNA Data
    10
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000628 Ensembl Gene Model | MGI Sequence Detail 49430 C57BL/6J ±  kb
    transcript ENSMUST00000000642 Ensembl | MGI Sequence Detail 5513 Not Applicable  
    polypeptide ENSMUSP00000000642 Ensembl | MGI Sequence Detail 917 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 5
      cDNA 11
      Primer pair 11
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141455
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 41
      Diseases 1
      Gene Ontology 18
      Phenotypes 49
    • Earliest
      J:34217 Tsao TS, et al., Regulation of hexokinase II gene expression by glucose flux in skeletal muscle. J Biol Chem. 1996 Jun 21;271(25):14959-63
    • Latest
      J:388028 Rueda EM, et al., Electron transport chain activity balances cell cycle progression and differentiation of retinal progenitor cells. Exp Eye Res. 2026 Jun 17;:111127
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory