Trip12 MGI Mouse Gene Detail - MGI:1309481 - thyroid hormone receptor interactor 12

About Help FAQ

Trip12 Gene Detail

Symbol

Trip12
Name

thyroid hormone receptor interactor 12
Synonyms

1110036I07Rik, 6720416K24Rik, Gtl6

Feature Type

protein coding gene
IDs

MGI:1309481
NCBI Gene: 14897
Alliance

genome feature page
Transcription Start Sites

26 TSS

more

Sequence Map

Chr1:84698910-84818237 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 43.42 cM, cytoband F
Mapping Data

3 experiments

more

SNPs within 2kb

1822 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1309481	protein coding gene	Chr1:84698910-84818285 (-)
129S1/SvImJ	ENSMUSG00200036842	protein coding gene	Chr1:82377155-82470956 (-)
A/J	ENSMUSG00195029172	protein coding gene	Chr1:81794299-81888116 (-)
AKR/J	ENSMUSG00220039813	protein coding gene	Chr1:82138907-82232565 (-)
BALB/cJ	ENSMUSG00180014317	protein coding gene	Chr1:82050735-82144553 (-)
C3H/HeJ	ENSMUSG00175001048	protein coding gene	Chr1:82211168-82304986 (-)
C57BL/6NJ	ENSMUSG00215021166	protein coding gene	Chr1:82125782-82219590 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014339	protein coding gene	Chr1:77772772-77889705 (-)
CAST/EiJ	ENSTCUG00005006959	protein coding gene	Chr1:81745681-81841938 (-)
CBA/J	ENSMUSG00210012280	protein coding gene	Chr1:81941668-82035319 (-)
DBA/2J	ENSMUSG00185016218	protein coding gene	Chr1:83005020-83098855 (-)
FVB/NJ	ENSMUSG00205025291	protein coding gene	Chr1:81533112-81626917 (-)
JF1/MsJ	ENSUMUG00000007516	protein coding gene	Chr1:81814043-81908288 (-)
LP/J	ENSMUSG00230013607	protein coding gene	Chr1:82942616-83036404 (-)
NOD/ShiLtJ	ENSMUSG00190025463	protein coding gene	Chr1:82159860-82253494 (-)
NZO/HlLtJ	ENSMUSG00225002428	protein coding gene	Chr1:86186415-86280235 (-)
PWK/PhJ	ENSLUMG00010043229	protein coding gene	Chr1:81405843-81499970 (-)
SPRET/EiJ	ENSMSPG00010039213	protein coding gene	Chr1:83742797-83865019 (-)
WSB/EiJ	ENSIUOG00005037820	protein coding gene	Chr1:81670148-81763933 (-)

more

Human Ortholog

TRIP12, thyroid hormone receptor interactor 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIP12, thyroid hormone receptor interactor 12
Synonyms

MRD49, TRIP-12, TRIPC, ULF
Links

HGNC:12306

NCBI Gene ID: 9320

UniProt: Q14669
Chr Location

2q36.3; chr2:229763835-229923239 (-) GRCh38

MGI Vertebrate Homology

Trip12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRIP12
Gene Tree

Trip12

more

Diseases

1 with human TRIP12 associations

				Human Disease	Mouse Models
				Clark-Baraitser syndrome IDs Clark-Baraitser syndrome DOID:0080234 MESH:C536208 OMIM:617752

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

8 phenotypes from 3 alleles in 2 genetic backgrounds
2 images
20 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

176
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

165
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Trip12
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

168 strains or lines available

Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development.

less

All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

624
Tissues

18
cDNA Data

31
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trip12

ZFIN trip12

less

All Sequences

198
RefSeq

100
UniProt

13
CCDS

CCDS35633.1

Ensembl

ENSMUSG00000026219 (Evidence)
NCBI Gene

14897

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000026219	Ensembl Gene Model \| MGI Sequence Detail	119328	C57BL/6J	± kb
	transcript	ENSMUST00000186465	Ensembl \| MGI Sequence Detail	9590	Not Applicable
	polypeptide	ENSMUSP00000140224	Ensembl \| MGI Sequence Detail	2025	Not Applicable

less

UniProt

13 Sequences
Protein Ontology

PR:000032653 E3 ubiquitin-protein ligase TRIP12

(term hierarchy)
EC

2.3.2.26
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR045322 E3 ubiquitin-protein ligase HECTD1/TRIP12-like

IPR057948 E3 ubiquitin-protein ligase TRIP12-like, TPR repeats

IPR000569 HECT domain

IPR035983 HECT, E3 ligase catalytic domain

IPR004170 WWE domain

IPR018123 WWE domain, subgroup

IPR037197 WWE domain superfamily
GlyGen

G5E870 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

less

All nucleic 31

cDNA 31

Microarray probesets 9

less

MGI:1921001, MGI:2142937, MGI:2444080

more

Summaries

All 57

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 20
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:389441 Schwarz LA, et al., Cortical development dynamics across autism spectrum disorder mouse models. Nature. 2026 Jun 17;

TSS for Trip12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12718	Chr1:84818317-84818333 (-)	-88 bp
Tssr12717	Chr1:84818223-84818261 (-)	-5 bp
Tssr12716	Chr1:84818186-84818200 (-)	44 bp
Tssr12715	Chr1:84818007-84818046 (-)	210 bp
Tssr12714	Chr1:84817979-84817995 (-)	250 bp
Tssr12713	Chr1:84817952-84817967 (-)	277 bp
Tssr12712	Chr1:84817914-84817923 (-)	318 bp
Tssr12711	Chr1:84817465-84817473 (-)	768 bp
Tssr12710	Chr1:84817300-84817312 (-)	931 bp
Tssr12709	Chr1:84817249-84817256 (-)	984 bp
Tssr12708	Chr1:84817200-84817211 (-)	1,031 bp
Tssr12707	Chr1:84817172-84817183 (-)	1,059 bp
Tssr12706	Chr1:84817141-84817162 (-)	1,085 bp
Tssr12705	Chr1:84817043-84817112 (-)	1,159 bp
Tssr12704	Chr1:84817031-84817042 (-)	1,200 bp
Tssr12703	Chr1:84817001-84817010 (-)	1,231 bp
Tssr12702	Chr1:84816706-84816743 (-)	1,512 bp
Tssr12701	Chr1:84816379-84816461 (-)	1,817 bp
Tssr12700	Chr1:84815550-84815561 (-)	2,681 bp
Tssr12699	Chr1:84815517-84815530 (-)	2,713 bp
Tssr12697	Chr1:84792601-84792616 (-)	25,628 bp
Tssr12696	Chr1:84789375-84789379 (-)	28,860 bp
Tssr12695	Chr1:84763847-84763856 (-)	54,385 bp
Tssr12694	Chr1:84743751-84743776 (-)	74,473 bp
Tssr12693	Chr1:84728258-84728261 (-)	89,977 bp
Tssr12692	Chr1:84722882-84722921 (-)	95,335 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24