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Cacybp Gene Detail
Summary
  • Symbol
    Cacybp
  • Name
    calcyclin binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270839
    NCBI Gene: 12301
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:160029937-160040445 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 69.61 cM, cytoband H1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    278 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270839
 protein coding gene Chr1:160029171-160040445 (-)
129S1/SvImJ ENSMUSG00200005308
 protein coding gene Chr1:157514517-157525020 (-)
A/J ENSMUSG00195021295
 protein coding gene Chr1:156862213-156872722 (-)
AKR/J ENSMUSG00220012611
 protein coding gene Chr1:156640174-156650682 (-)
BALB/cJ ENSMUSG00180033810
 protein coding gene Chr1:157084648-157095156 (-)
C3H/HeJ ENSMUSG00175037150
 protein coding gene Chr1:157149839-157160342 (-)
C57BL/6NJ ENSMUSG00215035425
 protein coding gene Chr1:157027873-157038381 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014754
 protein coding gene Chr1:150833680-150844106 (-)
CAST/EiJ ENSTCUG00005018889
 protein coding gene Chr1:155687189-155697696 (-)
CBA/J ENSMUSG00210020613
 protein coding gene Chr1:157040840-157051343 (-)
DBA/2J ENSMUSG00185043728
 protein coding gene Chr1:161305913-161316421 (-)
FVB/NJ ENSMUSG00205009931
 protein coding gene Chr1:156148491-156158999 (-)
JF1/MsJ ENSUMUG00000018659
 protein coding gene Chr1:160460767-160471252 (-)
LP/J ENSMUSG00230014063
 protein coding gene Chr1:160915950-160926453 (-)
NOD/ShiLtJ ENSMUSG00190027763
 protein coding gene Chr1:156887056-156897564 (-)
NZO/HlLtJ ENSMUSG00225003833
 protein coding gene Chr1:164532261-164542766 (-)
PWK/PhJ ENSLUMG00010039650
 protein coding gene Chr1:155852199-155862708 (-)
SPRET/EiJ ENSMSPG00010039565
 protein coding gene Chr1:159229262-159239784 (-)
WSB/EiJ ENSIUOG00005014857
 protein coding gene Chr1:156480564-156491069 (-)



Homology
more
  • Human Ortholog
    CACYBP, calcyclin binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CACYBP, calcyclin binding protein
  • Synonyms
    GIG5, PNAS-107, S100A6BP, SIP
  • Links
    NCBI Gene ID: 27101
    UniProt: Q9HB71

  • Chr Location
    1q25.1; chr1:174999163-175012027 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced thymus and spleen cellularity, and defects in TCR-rearrangement.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    889
  • Tissues
    52
  • cDNA Data
    115
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014226 Ensembl Gene Model | MGI Sequence Detail 10509 C57BL/6J ±  kb
    transcript ENSMUST00000014370 Ensembl | MGI Sequence Detail 2098 Not Applicable  
    polypeptide ENSMUSP00000014370 Ensembl | MGI Sequence Detail 229 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 116
      cDNA 115
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 17
    • Earliest
      J:47153 Filipek A, et al., Molecular cloning and expression of a mouse brain cDNA encoding a novel protein target of calcyclin. J Neurochem. 1998 May;70(5):1793-8
    • Latest
      J:373441 Cinquina V, et al., Astrocytes modulate neuronal development by S100A6 signaling. Nat Commun. 2025 Oct 13;16(1):9049
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory