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Pik3c2a Gene Detail
Summary
  • Symbol
    Pik3c2a
  • Name
    phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
  • Synonyms
    PI3KC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203729
    NCBI Gene: 18704
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:115936500-116042684 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 61.62 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1760 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203729
 protein coding gene Chr7:115936500-116042693 (-)
129S1/SvImJ ENSMUSG00200021845
 protein coding gene Chr7:102462372-102541211 (-)
A/J ENSMUSG00195032770
 protein coding gene Chr7:106983116-107064437 (-)
AKR/J ENSMUSG00220035505
 protein coding gene Chr7:100392862-100474181 (-)
BALB/cJ ENSMUSG00180032344
 protein coding gene Chr7:103652168-103733473 (-)
C3H/HeJ ENSMUSG00175020657
 protein coding gene Chr7:104258314-104339626 (-)
C57BL/6NJ ENSMUSG00215040196
 protein coding gene Chr7:103600629-103681950 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030357
 protein coding gene Chr7:118576115-118672770 (-)
CAST/EiJ ENSTCUG00005037659
 protein coding gene Chr7:106932693-107014018 (-)
CBA/J ENSMUSG00210024910
 protein coding gene Chr7:104084817-104166138 (-)
DBA/2J ENSMUSG00185021905
 protein coding gene Chr7:108435335-108516647 (-)
FVB/NJ ENSMUSG00205015569
 protein coding gene Chr7:104056156-104137479 (-)
JF1/MsJ ENSUMUG00000034724
 protein coding gene Chr7:113494816-113576149 (-)
LP/J ENSMUSG00230037703
 protein coding gene Chr7:114547187-114655505 (-)
NOD/ShiLtJ ENSMUSG00190016734
 protein coding gene Chr7:104277415-104358741 (-)
NZO/HlLtJ ENSMUSG00225039056
 protein coding gene Chr7:112795682-112876999 (-)
PWK/PhJ ENSLUMG00010010883
 protein coding gene Chr7:102647145-102728125 (-)
SPRET/EiJ ENSMSPG00010007419
 protein coding gene Chr7:103858409-103953077 (-)
WSB/EiJ ENSIUOG00005010319
 protein coding gene Chr7:104933807-105015107 (-)



Homology
more
  • Human Ortholog
    PIK3C2A, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3C2A, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
  • Synonyms
    CPK, OCSKD, PI3-K-C2A, PI3-K-C2(ALPHA), PI3K-C2-alpha, PI3K-C2alpha
  • Links
    NCBI Gene ID: 5286
    UniProt: O00443

  • Chr Location
    11p15.1; chr11:17077730-17207986 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    83 phenotypes from 4 alleles in 5 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele show chronic renal failure and a range of renal lesions that precede immune involvement. Mice heterozygous for a kinase-inactivating allele show defects in platelet formation, platelet membrane morphology and dynamics, and an enrichment of barbell pro-platelets. Homozygosity for a kinase-dead allele is embryonic lethal, while heterozygosity affects leptin levels in males, leading to increased food intake, age-related obesity, insulin resistance, hyperinsulinemia, hyperglycemia and steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    693
  • Tissues
    96
  • cDNA Data
    109
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030660 Ensembl Gene Model | MGI Sequence Detail 106185 C57BL/6J ±  kb
    transcript ENSMUST00000170430 Ensembl | MGI Sequence Detail 8044 Not Applicable  
    polypeptide ENSMUSP00000126092 Ensembl | MGI Sequence Detail 1686 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 110
      Primer pair 1
      Antibodies 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:33383 Molz L, et al., Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain. J Biol Chem. 1996 Jun 7;271(23):13892-9
    • Latest
      J:370019 Posor Y, et al., Inactivation of PI3K-C2alpha deregulates cell death pathways and sensitizes to endotoxic shock. Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2423358122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory