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Dgcr6 Gene Detail
Summary
  • Symbol
    Dgcr6
  • Name
    DiGeorge syndrome critical region gene 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202877
    NCBI Gene: 13353
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17870736-17889497 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.19 cM, cytoband B2
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202877
 protein coding gene Chr16:17870724-17889497 (+)
129S1/SvImJ ENSMUSG00200045146
 protein coding gene Chr16:14867287-14886069 (+)
A/J ENSMUSG00195032253
 protein coding gene Chr16:14424579-14443367 (+)
AKR/J ENSMUSG00220038867
 protein coding gene Chr16:14740860-14759646 (+)
BALB/cJ ENSMUSG00180028863
 protein coding gene Chr16:14665838-14684628 (+)
C3H/HeJ ENSMUSG00175037947
 protein coding gene Chr16:14810842-14829632 (+)
C57BL/6NJ ENSMUSG00215032335
 protein coding gene Chr16:14531949-14550741 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020535
 protein coding gene Chr16:14549045-14567788 (+)
CAST/EiJ ENSTCUG00005045296
 protein coding gene Chr16:14749954-14756310 (+)
CBA/J ENSMUSG00210039055
 protein coding gene Chr16:14827142-14845934 (+)
DBA/2J ENSMUSG00185027081
 protein coding gene Chr16:14773309-14792109 (+)
FVB/NJ ENSMUSG00205045294
 protein coding gene Chr16:14780933-14799715 (+)
JF1/MsJ ENSUMUG00000051539
 protein coding gene Chr16:14877589-14883946 (+)
LP/J ENSMUSG00230037621
 protein coding gene Chr16:17351154-17369942 (+)
NOD/ShiLtJ ENSMUSG00190032085
 protein coding gene Chr16:14913201-14931984 (+)
NZO/HlLtJ ENSMUSG00225037511
 protein coding gene Chr16:20597010-20615799 (+)
PWK/PhJ ENSLUMG00010040489
 protein coding gene Chr16:14750982-14757353 (+)
SPRET/EiJ ENSMSPG00010036828
 protein coding gene Chr16:14769781-14776138 (+)
WSB/EiJ ENSIUOG00005034997
 protein coding gene Chr16:14907520-14926283 (+)



Homology
more
  • Human Ortholog
    DGCR6, DiGeorge syndrome critical region gene 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGCR6, DiGeorge syndrome critical region gene 6
  • Links
    NCBI Gene ID: 8214
    UniProt: Q14129

  • Chr Location
    22q11.21; chr22:18905677-18914281 (+)  GRCh38
  • Human Ortholog
    DGCR6L, DiGeorge syndrome critical region gene 6 like
  • Synonyms
    DGCR6
  • Links
    NCBI Gene ID: 85359
    UniProt: Q9BY27

  • Chr Location
    chr22:20314238-20320080 (-)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    152 phenotype references
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    677
  • Tissues
    60
  • cDNA Data
    51
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13353 NCBI Gene Model | MGI Sequence Detail 18762 C57BL/6J ±  kb
transcript NM_001416778 RefSeq | MGI Sequence Detail 1865 ZRU/MplStud  
polypeptide O35347 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 81
    Genomic 29
    cDNA 51
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2146581
References
more
  • Summaries
    All 184
    Developmental Gene Expression 5
    Diseases 6
    Phenotypes 152
  • Earliest
    J:44451 Botta A, et al., Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation. Mamm Genome. 1997 Dec;8(12):890-5
  • Latest
    J:390319 Son GY, et al., Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome. Cell Rep. 2026 Jul 1;:117619
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory