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Dpagt1 Gene Detail
Summary
  • Symbol
    Dpagt1
  • Name
    dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
  • Synonyms
    Dpagt2, Gnpta, GPT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196396
    NCBI Gene: 13478
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44237316-44245197 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    289 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196396
 protein coding gene Chr9:44237314-44247374 (+)
129S1/SvImJ ENSMUSG00200018429
 protein coding gene Chr9:41321604-41323751 (+)
A/J ENSMUSG00195022010
 protein coding gene Chr9:41063964-41072012 (+)
AKR/J ENSMUSG00220037306
 protein coding gene Chr9:41161359-41169415 (+)
BALB/cJ ENSMUSG00180024271
 protein coding gene Chr9:41175678-41183727 (+)
C3H/HeJ ENSMUSG00175013768
 protein coding gene Chr9:41187384-41195432 (+)
C57BL/6NJ ENSMUSG00215031890
 protein coding gene Chr9:41157545-41165601 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032109
 protein coding gene Chr9:41199595-41206387 (+)
CAST/EiJ ENSTCUG00005015376
 protein coding gene Chr9:41150838-41158863 (+)
CBA/J ENSMUSG00210015969
 protein coding gene Chr9:41241121-41249171 (+)
DBA/2J ENSMUSG00185010597
 protein coding gene Chr9:41302330-41310377 (+)
FVB/NJ ENSMUSG00205027597
 protein coding gene Chr9:41560829-41568887 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230039863
 protein coding gene Chr9:41603995-41620413 (+)
NOD/ShiLtJ ENSMUSG00190021170
 protein coding gene Chr9:41381273-41389320 (+)
NZO/HlLtJ ENSMUSG00225041725
 protein coding gene Chr9:41564793-41572842 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010008409
 protein coding gene Chr9:42084031-42094213 (+)
WSB/EiJ ENSIUOG00005020560
 protein coding gene Chr9:40798209-40806251 (+)



Homology
more
  • Human Ortholog
    DPAGT1, dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPAGT1, dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
  • Synonyms
    ALG7, CDG1J, CDG-Ij, CMS13, CMSTA2, D11S366, DGPT, DPAGT, DPAGT2, G1PT, GPT, UAGT, UGAT
  • Links
    NCBI Gene ID: 1798
    UniProt: Q9H3H5

  • Chr Location
    11q23.3; chr11:119093874-119108331 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human DPAGT1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display an embryonic lethal phenotype due to widespread cell death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    95
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032123 Ensembl Gene Model | MGI Sequence Detail 7882 C57BL/6J ±  kb
transcript ENSMUST00000054708 Ensembl | MGI Sequence Detail 2205 Not Applicable  
polypeptide ENSMUSP00000056282 Ensembl | MGI Sequence Detail 410 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 105
    Genomic 10
    cDNA 95

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10207, MGI:2143209, MGI:95788
References
more
  • Summaries
    All 51
    Developmental Gene Expression 1
    Gene Ontology 13
    Phenotypes 11
  • Earliest
    J:47505 Varki A, et al., Demonstration of the heterozygous state for I-cell disease and pseudo-Hurler polydystrophy by assay of N-acetylglucosaminylphosphotransferase in white blood cells and fibroblasts. Am J Hum Genet. 1982 Sep;34(5):717-29
  • Latest
    J:330704 Richards CM, et al., The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection. Science. 2022 Sep 8;:eabn5648
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory