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Tsc22d3 Gene Detail
Summary
  • Symbol
    Tsc22d3
  • Name
    TSC22 domain family, member 3
  • Synonyms
    Dsip1, Gilz
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196284
    NCBI Gene: 14605
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:139440277-139501257 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 61.35 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    966 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196284
 protein coding gene ChrX:139440277-139501408 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036135
 protein coding gene ChrX:138096642-138158932 (-)
A/J MGP_AJ_G0036113
 protein coding gene ChrX:137470266-137534807 (-)
AKR/J MGP_AKRJ_G0036038
 protein coding gene ChrX:141872403-141935263 (-)
BALB/cJ MGP_BALBcJ_G0036103
 protein coding gene ChrX:135781276-135842512 (-)
C3H/HeJ MGP_C3HHeJ_G0035812
 protein coding gene ChrX:138104956-138172518 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036628
 protein coding gene ChrX:142138902-142199798 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033452
 protein coding gene ChrX:129193047-129254236 (-)
CAST/EiJ MGP_CASTEiJ_G0035103
 protein coding gene ChrX:118921016-118981423 (-)
CBA/J MGP_CBAJ_G0035789
 protein coding gene ChrX:146510035-146574799 (-)
DBA/2J MGP_DBA2J_G0035946
 protein coding gene ChrX:136611015-136673138 (-)
FVB/NJ MGP_FVBNJ_G0035880
 protein coding gene ChrX:135842963-135904092 (-)
LP/J MGP_LPJ_G0036037
 protein coding gene ChrX:139044594-139107995 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035917
 protein coding gene ChrX:154021172-154085322 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036664
 protein coding gene ChrX:137398532-137460079 (-)
PWK/PhJ MGP_PWKPhJ_G0034796
 protein coding gene ChrX:115819775-115878820 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034622
 protein coding gene ChrX:119458590-119525027 (-)
WSB/EiJ MGP_WSBEiJ_G0035238
 protein coding gene ChrX:135719488-135781049 (-)



Homology
more
  • Human Ortholog
    TSC22D3, TSC22 domain family member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSC22D3, TSC22 domain family member 3
  • Synonyms
    DIP, DSIPI, GILZ, TSC-22R
  • Links
    NCBI Gene ID: 1831
    UniProt: Q99576

  • Chr Location
    Xq22.3; chrX:107713221-107777342 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 5 alleles in 6 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hemizygous null males show mild deficits in sodium handling, weight reduction, hyperinsulinemia, resistance to liver steatosis, and sterility associated with azoospermia, testis dysplasia, Leydig cell hyperplasia, male germ cell apoptosis, arrested meiosis, and high FSH and testosterone levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    68
  • cDNA Data
    110
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14605 NCBI Gene Model | MGI Sequence Detail 60981 C57BL/6J ±  kb
    transcript NM_010286 RefSeq | MGI Sequence Detail 2600 C57BL/6  
    polypeptide Q9Z2S7 UniProt | EBI | MGI Sequence Detail 137 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 110
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 14
      Gene Ontology 8
      Phenotypes 25
    • Earliest
      J:45108 D'Adamio F, et al., A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. Immunity. 1997 Dec;7(6):803-12
    • Latest
      J:373924 Young JC, et al., The nuclear transport factor IPO5 revealed as a critical mediator of male germline development. Biol Reprod. 2025 Oct 14;113(4):917-933
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory