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Mr1 Gene Detail
Summary
  • Symbol
    Mr1
  • Name
    major histocompatibility complex, class I-related
  • Synonyms
    H2ls, MR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195463
    NCBI Gene: 15064
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:155003620-155022560 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 66.45 cM, cytoband H1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    553 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195463
 protein coding gene Chr1:155003023-155022560 (-)
129S1/SvImJ ENSMUSG00200002439
 protein coding gene Chr1:152445841-152465364 (-)
A/J ENSMUSG00195013885
 protein coding gene Chr1:151833846-151853369 (-)
AKR/J ENSMUSG00220004909
 protein coding gene Chr1:151633061-151652584 (-)
BALB/cJ ENSMUSG00180029388
 protein coding gene Chr1:152053139-152072658 (-)
C3H/HeJ ENSMUSG00175002583
 protein coding gene Chr1:152092281-152111808 (-)
C57BL/6NJ ENSMUSG00215003384
 protein coding gene Chr1:151988794-152008325 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014722
 protein coding gene Chr1:145833404-145853107 (-)
CAST/EiJ ENSTCUG00005005286
 protein coding gene Chr1:150635847-150655417 (-)
CBA/J ENSMUSG00210030633
 protein coding gene Chr1:151995723-152015242 (-)
DBA/2J ENSMUSG00185040169
 protein coding gene Chr1:156271875-156291410 (-)
FVB/NJ ENSMUSG00205026661
 protein coding gene Chr1:151128074-151147594 (-)
JF1/MsJ ENSUMUG00000016754
 protein coding gene Chr1:155428923-155448462 (-)
LP/J ENSMUSG00230015192
 protein coding gene Chr1:155828328-155848108 (-)
NOD/ShiLtJ ENSMUSG00190012169
 protein coding gene Chr1:151843858-151863381 (-)
NZO/HlLtJ ENSMUSG00225005180
 protein coding gene Chr1:159508980-159528503 (-)
PWK/PhJ ENSLUMG00010026821
 protein coding gene Chr1:150778444-150797947 (-)
SPRET/EiJ ENSMSPG00010037761
 protein coding gene Chr1:154120673-154139158 (-)
WSB/EiJ ENSIUOG00005021822
 protein coding gene Chr1:151410329-151429888 (-)



Homology
more
  • Human Ortholog
    MR1, major histocompatibility complex, class I-related
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MR1, major histocompatibility complex, class I-related
  • Synonyms
    HLALS
  • Links
    NCBI Gene ID: 3140
    UniProt: Q95460

  • Chr Location
    1q25.3; chr1:181033374-181061938 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 4 genetic backgrounds
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null homozyogtes lack mucosal-associated invariant T cells that express the canonical mVa19-Ja33 rearrangement of the Tcra gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15064 NCBI Gene Model | MGI Sequence Detail 18941 C57BL/6J ±  kb
    transcript NM_008209 RefSeq | MGI Sequence Detail 2555 C57BL/6  
    polypeptide Q8HWB0 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000001819 MHC class I-related gene protein
      (term hierarchy)
    • PDB
      8VZ8, 8VZ9
    • InterPro Domains
      IPR050208 Antigen-presenting and immune regulatory MHC class I-related
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR011162 MHC classes I/II-like antigen recognition protein
      IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
      IPR011161 MHC class I-like antigen recognition-like
      IPR037055 MHC class I-like antigen recognition-like superfamily
    • GlyGen
      Q8HWB0 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 5
      cDNA 23

      Microarray probesets 4
    References
    more
    • Summaries
      All 108
      Gene Ontology 10
      Phenotypes 64
    • Earliest
      J:43255 Yamaguchi H, et al., A highly conserved major histocompatibility complex class I-related gene in mammals. Biochem Biophys Res Commun. 1997 Sep 29;238(3):697-702
    • Latest
      J:389320 Abdelsalam AM, et al., IFNgamma-producing iNKTs restrict a live-attenuated chlamydia oral vaccine in the large intestine. Front Immunol. 2026;17:1851941
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory