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Hdgf Gene Detail
Summary
  • Symbol
    Hdgf
  • Name
    heparin binding growth factor
  • Synonyms
    D3Ertd299e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194494
    NCBI Gene: 15191
  • Alliance
    genome feature page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87813844-87823439 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194494
 protein coding gene Chr3:87813628-87823439 (+)
129S1/SvImJ ENSMUSG00200039053
 protein coding gene Chr3:84668444-84678258 (+)
A/J ENSMUSG00195051320
 protein coding gene Chr3:84690660-84700479 (+)
AKR/J ENSMUSG00220047131
 protein coding gene Chr3:84638641-84648457 (+)
BALB/cJ ENSMUSG00180043154
 protein coding gene Chr3:84808259-84818074 (+)
C3H/HeJ ENSMUSG00175045357
 protein coding gene Chr3:84618390-84628207 (+)
C57BL/6NJ ENSMUSG00215047525
 protein coding gene Chr3:85056167-85065978 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025144
 protein coding gene Chr3:80671375-80680788 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210042680
 protein coding gene Chr3:84761410-84771227 (+)
DBA/2J ENSMUSG00185049300
 protein coding gene Chr3:84896957-84906772 (+)
FVB/NJ ENSMUSG00205043590
 protein coding gene Chr3:83685836-83695660 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230029978
 protein coding gene Chr3:86889887-86899699 (+)
NOD/ShiLtJ ENSMUSG00190048874
 protein coding gene Chr3:85138057-85147880 (+)
NZO/HlLtJ ENSMUSG00225005483
 protein coding gene Chr3:89643868-89653684 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HDGF, heparin binding growth factor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDGF, heparin binding growth factor
  • Synonyms
    HMG1L2
  • Links
    NCBI Gene ID: 3068
    UniProt: P51858

  • Chr Location
    1q23.1; chr1:156742107-156767366 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted disruption of this gene are viable and fertile and display no major morphological, biochemical or behavioral phenotypes except for a significant reduction in rearing activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    38
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    55
  • cDNA Data
    290
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15191 NCBI Gene Model | MGI Sequence Detail 9596 C57BL/6J ±  kb
transcript NM_001410039 RefSeq | MGI Sequence Detail 2202 ZRU/MplStud  
polypeptide P51859 UniProt | EBI | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 293
    cDNA 291
    Primer pair 2
    Antibodies 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:1098788, MGI:2139627
References
more
  • Summaries
    All 60
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 12
    Phenotypes 15
  • Earliest
    J:42918 Izumoto Y, et al., Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus. Biochem Biophys Res Commun. 1997 Sep 8;238(1):26-32
  • Latest
    J:358217 Hu TH, et al., HDGF stimulates liver tumorigenesis by enhancing reactive oxygen species generation in mitochondria. J Biol Chem. 2023 Oct 10;299(11):105335
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory