About   Help   FAQ
Hdgfl2 Gene Detail
Summary
  • Symbol
    Hdgfl2
  • Name
    HDGF like 2
  • Synonyms
    Hdgfrp2, HRP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194492
    NCBI Gene: 15193
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56386661-56407605 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.15 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    358 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194492
 protein coding gene Chr17:56386634-56407607 (+)
129S1/SvImJ ENSMUSG00200016476
 protein coding gene Chr17:51661718-51682685 (+)
A/J ENSMUSG00195006807
 protein coding gene Chr17:53049146-53070111 (+)
AKR/J ENSMUSG00220012065
 protein coding gene Chr17:52098584-52119550 (+)
BALB/cJ ENSMUSG00180006037
 protein coding gene Chr17:52806779-52827746 (+)
C3H/HeJ ENSMUSG00175007123
 protein coding gene Chr17:52122844-52143808 (+)
C57BL/6NJ ENSMUSG00215008409
 protein coding gene Chr17:51736970-51757935 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021763
 protein coding gene Chr17:52669605-52686548 (+)
CAST/EiJ ENSTCUG00005017791
 protein coding gene Chr17:52855875-52876600 (+)
CBA/J ENSMUSG00210026731
 protein coding gene Chr17:51889907-51910873 (+)
DBA/2J ENSMUSG00185009083
 protein coding gene Chr17:54759765-54780730 (+)
FVB/NJ ENSMUSG00205006868
 protein coding gene Chr17:52437413-52458382 (+)
JF1/MsJ ENSUMUG00000024650
 protein coding gene Chr17:54437657-54458365 (+)
LP/J ENSMUSG00230024896
 protein coding gene Chr17:55739148-55760114 (+)
NOD/ShiLtJ ENSMUSG00190009371
 protein coding gene Chr17:51892609-51913578 (+)
NZO/HlLtJ ENSMUSG00225042060
 protein coding gene Chr17:58022978-58043942 (+)
PWK/PhJ ENSLUMG00010008919
 protein coding gene Chr17:51698697-51719405 (+)
SPRET/EiJ ENSMSPG00010004926
 protein coding gene Chr17:52015429-52035408 (+)
WSB/EiJ ENSIUOG00005022192
 protein coding gene Chr17:52799274-52820246 (+)



Homology
more
  • Human Ortholog
    HDGFL2, HDGF like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDGFL2, HDGF like 2
  • Synonyms
    HDGF-2, HDGF2, HDGFRP2, HRP-2, HRP2
  • Links
    NCBI Gene ID: 84717
    UniProt: Q7Z4V5

  • Chr Location
    19p13.3; chr19:4472244-4502220 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit an increased mean serum alkaline phosphatase level compared to controls. Female mutants exhibited a decreased mean skin fibroblast proliferation rate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    610
  • Tissues
    10
  • cDNA Data
    111
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15193 NCBI Gene Model | MGI Sequence Detail 20945 C57BL/6J ±  kb
    transcript NM_001304784 RefSeq | MGI Sequence Detail 2283 C57BL/6  
    polypeptide Q3UMU9 UniProt | EBI | MGI Sequence Detail 669 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008492 hepatoma-derived growth factor-related protein 2
      (term hierarchy)
    • InterPro Domains
      IPR036218 HIV integrase-binding domain superfamily
      IPR021567 Lens epithelium-derived growth factor, integrase-binding domain
      IPR000313 PWWP domain
      IPR035441 TFIIS/LEDGF domain superfamily
    • GlyGen
      Q3UMU9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 111

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5883594
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:42918 Izumoto Y, et al., Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus. Biochem Biophys Res Commun. 1997 Sep 8;238(1):26-32
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory