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Synpo Gene Detail
Summary
  • Symbol
    Synpo
  • Name
    synaptopodin
  • Synonyms
    9030217H17Rik, 9330140I15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099446
    NCBI Gene: 104027
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:60727045-60793214 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1708 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099446
 protein coding gene Chr18:60727045-60793241 (-)
129S1/SvImJ ENSMUSG00200030553
 protein coding gene Chr18:57888220-57942562 (-)
A/J ENSMUSG00195005158
 protein coding gene Chr18:57950023-58004532 (-)
AKR/J ENSMUSG00220015889
 protein coding gene Chr18:57943600-57997952 (-)
BALB/cJ ENSMUSG00180011568
 protein coding gene Chr18:58521654-58576167 (-)
C3H/HeJ ENSMUSG00175033720
 protein coding gene Chr18:58139548-58193897 (-)
C57BL/6NJ ENSMUSG00215035950
 protein coding gene Chr18:57459394-57513744 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022309
 protein coding gene Chr18:57376595-57444633 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210029664
 protein coding gene Chr18:58084371-58138885 (-)
DBA/2J ENSMUSG00185015477
 protein coding gene Chr18:57986807-58041154 (-)
FVB/NJ ENSMUSG00205015760
 protein coding gene Chr18:57471288-57525642 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230011087
 protein coding gene Chr18:60047896-60102239 (-)
NOD/ShiLtJ ENSMUSG00190025321
 protein coding gene Chr18:57739771-57794156 (-)
NZO/HlLtJ ENSMUSG00225034882
 protein coding gene Chr18:59924358-59978700 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SYNPO, synaptopodin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYNPO, synaptopodin
  • Synonyms
    SYNPO1
  • Links
    NCBI Gene ID: 11346
    UniProt: Q8N3V7

  • Chr Location
    5q33.1; chr5:150586010-150659208 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in telencephalic neurons, reduced long term potentiation, and behavioral abnormalities including hypoactivity, reduced anxiety, and learning deficiencies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    51
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    127
  • cDNA Data
    22
  • Literature Summary
    40
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043079 Ensembl Gene Model | MGI Sequence Detail 66170 C57BL/6J ±  kb
transcript ENSMUST00000130360 Ensembl | MGI Sequence Detail 5159 Not Applicable  
polypeptide ENSMUSP00000115355 Ensembl | MGI Sequence Detail 1100 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 22
    Primer pair 2
    Antibodies 4

    Microarray probesets 5
Other
Accession IDs
less
MGI:1924944, MGI:2147341, MGI:2442267
References
more
  • Summaries
    All 134
    Developmental Gene Expression 40
    Gene Ontology 13
    Phenotypes 23
  • Earliest
    J:43510 Mundel P, et al., Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol. 1997 Oct 6;139(1):193-204
  • Latest
    J:378181 Lin MH, et al., Mouse Alport podocytes are susceptible to AAV9 transduction in vivo. Kidney Int. 2026 Jan;109(1):129-138
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory