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Erc2 Gene Detail
Summary
  • Symbol
    Erc2
  • Name
    ELKS/RAB6-interacting/CAST family member 2
  • Synonyms
    CAST, D14Ertd171e, ELKS2alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098749
    NCBI Gene: 238988
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:27344385-28200494 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 16.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22063 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098749
 protein coding gene Chr14:27344232-28200494 (+)
129S1/SvImJ ENSMUSG00200013950
 protein coding gene Chr14:19408704-19850100 (+)
129S1/SvImJ ENSMUSGG00200054691
 protein coding gene Chr14:19185220-19186335 (+)
A/J ENSMUSGG00195055347
 protein coding gene Chr14:20252086-20253201 (+)
A/J ENSMUSG00195021897
 protein coding gene Chr14:20473948-20918660 (+)
AKR/J ENSMUSG00220023748
 protein coding gene Chr14:19577967-20022695 (+)
AKR/J ENSMUSGG00220054608
 protein coding gene Chr14:19356098-19357213 (+)
BALB/cJ ENSMUSG00180036046
 protein coding gene Chr14:19565814-20010490 (+)
BALB/cJ ENSMUSGG00180055292
 protein coding gene Chr14:19343966-19345081 (+)
C3H/HeJ ENSMUSG00175023128
 protein coding gene Chr14:19633258-20077928 (+)
C3H/HeJ ENSMUSGG00175054814
 protein coding gene Chr14:19411438-19412553 (+)
C57BL/6NJ ENSMUSG00215030953
 protein coding gene Chr14:19879669-20321023 (+)
C57BL/6NJ ENSMUSGG00215055648
 protein coding gene Chr14:19656188-19657303 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019041
 protein coding gene Chr14:19957204-20803933 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054625
 protein coding gene Chr14:19646311-19647426 (+)
CBA/J ENSMUSG00210026377
 protein coding gene Chr14:19868131-20314658 (+)
DBA/2J ENSMUSGG00185057350
 protein coding gene Chr14:23938521-23939636 (+)
DBA/2J ENSMUSG00185037392
 protein coding gene Chr14:24161999-24603361 (+)
FVB/NJ ENSMUSG00205020237
 protein coding gene Chr14:19696027-20135583 (+)
FVB/NJ ENSMUSGG00205054579
 protein coding gene Chr14:19474159-19475274 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230037594
 protein coding gene Chr14:31437589-31878954 (+)
LP/J ENSMUSGG00230055485
 protein coding gene Chr14:31214131-31215246 (+)
NOD/ShiLtJ ENSMUSGG00190055028
 protein coding gene Chr14:19663697-19664812 (+)
NOD/ShiLtJ ENSMUSG00190024205
 protein coding gene Chr14:19885519-20330255 (+)
NZO/HlLtJ ENSMUSG00225036343
 protein coding gene Chr14:25764672-26209338 (+)
NZO/HlLtJ ENSMUSGG00225055231
 protein coding gene Chr14:25541220-25542335 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010032840
 protein coding gene Chr14:21271238-22127299 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ERC2, ELKS/RAB6-interacting/CAST family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERC2, ELKS/RAB6-interacting/CAST family member 2
  • Synonyms
    CAST, CAST1, ELKSL, SPBC110, Spc110
  • Links
    NCBI Gene ID: 26059
    UniProt: O15083

  • Chr Location
    3p14.3; chr3:55508286-56469095 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted disruptions of this gene are viable and fertile. However, homozygotes for one allele display abnormal CNS synaptic transmission. Homozygotes for a second allele display retinal abnormalities and impaired vision.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    65
  • cDNA Data
    15
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040640 Ensembl Gene Model | MGI Sequence Detail 856110 C57BL/6J ±  kb
    transcript ENSMUST00000090302 Ensembl | MGI Sequence Detail 6083 Not Applicable  
    polypeptide ENSMUSP00000087773 Ensembl | MGI Sequence Detail 1002 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 13
      Gene Ontology 10
      Phenotypes 30
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:389879 Emperador-Melero J, et al., Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release. Elife. 2026 Jun 17;14
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory