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Clk4 Gene Detail
Summary
  • Symbol
    Clk4
  • Name
    CDC like kinase 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098551
    NCBI Gene: 12750
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:51153941-51172597 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    393 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098551
 protein coding gene Chr11:51152557-51172597 (+)
129S1/SvImJ ENSMUSG00200039696
 protein coding gene Chr11:48151236-48159550 (+)
129S1/SvImJ ENSMUSGG00200054519
 protein coding gene Chr11:48144956-48149807 (+)
A/J ENSMUSGG00195055047
 protein coding gene Chr11:48087979-48092832 (+)
A/J ENSMUSG00195031150
 protein coding gene Chr11:48094261-48102576 (+)
AKR/J ENSMUSG00220030809
 protein coding gene Chr11:48283108-48291423 (+)
AKR/J ENSMUSGG00220054451
 protein coding gene Chr11:48276828-48281679 (+)
BALB/cJ ENSMUSGG00180055512
 protein coding gene Chr11:48149409-48154262 (+)
C3H/HeJ ENSMUSGG00175055042
 protein coding gene Chr11:48119506-48124357 (+)
C3H/HeJ ENSMUSG00175035852
 protein coding gene Chr11:48125786-48134101 (+)
C57BL/6NJ ENSMUSGG00215055324
 protein coding gene Chr11:48020898-48025749 (+)
C57BL/6NJ ENSMUSG00215032135
 protein coding gene Chr11:48027178-48035493 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016308
 protein coding gene Chr11:46167389-46187219 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055056
 protein coding gene Chr11:47975500-47980351 (+)
CBA/J ENSMUSG00210028826
 protein coding gene Chr11:47981780-47990095 (+)
DBA/2J ENSMUSGG00185057540
 protein coding gene Chr11:48184795-48189635 (+)
DBA/2J ENSMUSG00185025768
 protein coding gene Chr11:48191064-48199166 (+)
FVB/NJ ENSMUSGG00205054175
 protein coding gene Chr11:48017841-48022692 (+)
FVB/NJ ENSMUSG00205019479
 protein coding gene Chr11:48024121-48032436 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055449
 protein coding gene Chr11:49368739-49373590 (+)
LP/J ENSMUSG00230030609
 protein coding gene Chr11:49375019-49383333 (+)
NOD/ShiLtJ ENSMUSGG00190054689
 protein coding gene Chr11:48248596-48253436 (+)
NOD/ShiLtJ ENSMUSG00190032241
 protein coding gene Chr11:48254865-48262963 (+)
NZO/HlLtJ ENSMUSG00225030709
 protein coding gene Chr11:51403346-51411445 (+)
NZO/HlLtJ ENSMUSGG00225055327
 protein coding gene Chr11:51397081-51401917 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010017837
 protein coding gene Chr11:48663108-48682536 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CLK4, CDC like kinase 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLK4, CDC like kinase 4
  • Links
    NCBI Gene ID: 57396
    UniProt: Q9HAZ1

  • Chr Location
    5q35.3; chr5:178602664-178630615 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in cardiomyocytes exhibit congestive heart failure, enlarged hearts and lungs, cardiac interstitial fibrosis, and abnormal cardiomyocyte sarcomere morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    617
  • Tissues
    16
  • cDNA Data
    98
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12750 NCBI Gene Model | MGI Sequence Detail 18657 C57BL/6J ±  kb
    transcript NM_001430880 RefSeq | MGI Sequence Detail 3350 C57BL/6  
    polypeptide O35493 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 102
      cDNA 99
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144335, MGI:2144675
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:327369 Huang J, et al., CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation. Nat Commun. 2022 Jul 30;13(1):4433
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory