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Gamt Gene Detail
Summary
  • Symbol
    Gamt
  • Name
    guanidinoacetate methyltransferase
  • Synonyms
    Spintz1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098221
    NCBI Gene: 14431
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80093985-80096846 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098221
 protein coding gene Chr10:80093985-80096846 (-)
129S1/SvImJ ENSMUSG00200048176
 protein coding gene Chr10:76717650-76720511 (-)
A/J ENSMUSG00195040900
 protein coding gene Chr10:77113209-77116070 (-)
AKR/J ENSMUSG00220045970
 protein coding gene Chr10:76710769-76713630 (-)
BALB/cJ ENSMUSG00180048802
 protein coding gene Chr10:77123713-77126574 (-)
C3H/HeJ ENSMUSG00175052276
 protein coding gene Chr10:76994381-76997242 (-)
C57BL/6NJ ENSMUSG00215048422
 protein coding gene Chr10:76736115-76738976 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015573
 protein coding gene Chr10:74245167-74247928 (-)
CAST/EiJ ENSTCUG00005049833
 protein coding gene Chr10:76620942-76623809 (-)
CBA/J ENSMUSG00210039019
 protein coding gene Chr10:76850448-76853309 (-)
DBA/2J ENSMUSG00185044941
 protein coding gene Chr10:77192850-77195711 (-)
FVB/NJ ENSMUSG00205043558
 protein coding gene Chr10:76905630-76908491 (-)
JF1/MsJ ENSUMUG00000047206
 protein coding gene Chr10:78421497-78424360 (-)
LP/J ENSMUSG00230044477
 protein coding gene Chr10:78962585-78965446 (-)
NOD/ShiLtJ ENSMUSG00190035992
 protein coding gene Chr10:77106574-77109435 (-)
NZO/HlLtJ ENSMUSG00225049032
 protein coding gene Chr10:83248939-83251800 (-)
PWK/PhJ ENSLUMG00010036338
 protein coding gene Chr10:76782868-76785731 (-)
SPRET/EiJ ENSMSPG00010040437
 protein coding gene Chr10:78404922-78407793 (-)
WSB/EiJ ENSIUOG00005050991
 protein coding gene Chr10:76810575-76813436 (-)



Homology
more
  • Human Ortholog
    GAMT, guanidinoacetate N-methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAMT, guanidinoacetate N-methyltransferase
  • Synonyms
    CCDS2, HEL-S-20, PIG2, TP53I2
  • Links
    NCBI Gene ID: 2593
    UniProt: Q14353

  • Chr Location
    19p13.3; chr19:1397026-1401570 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gamt mouse models; 2 with human GAMT associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display increased postnatal lethality; reduced body weight, muscle tension, and creatine concentrations; infertility with impaired spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    633
  • Tissues
    16
  • cDNA Data
    71
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14431 NCBI Gene Model | MGI Sequence Detail 2862 C57BL/6J ±  kb
    transcript NM_001347119 RefSeq | MGI Sequence Detail 1052 ZRU/MplStud  
    polypeptide O35969 UniProt | EBI | MGI Sequence Detail 236 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007835 guanidinoacetate N-methyltransferase
      (term hierarchy)
    • EC
      2.1.1.2
    • InterPro Domains
      IPR026480 Arginine N-methyltransferase 2-like domain
      IPR016550 Guanidinoacetate N-methyltransferase
      IPR051038 RMT2/GAMT Methyltransferase
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    • GlyGen
      O35969 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 1
      cDNA 71
      Primer pair 4
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143491
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 12
      Phenotypes 27
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:361380 Kuribayashi S, et al., Intratesticular creatine maintains spermatogenesis by defining tight junctions. Sci Rep. 2024 Dec 28;14(1):30692
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory